Gcn5 histone acetyltransferase is present in the mitoplasts

被引：13
|
作者：
Montanari, Arianna [1 ,2 ]
Leo, Manuela [1 ]
De Luca, Veronica [1 ]
Filetici, Patrizia [3 ]
Francisci, Silvia [1 ]
机构：
[1] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Piazzale Aldo Moro 5, I-00185 Rome, Italy
[2] Sapienza Univ Rome, Pasteur Inst Italy, Cenci Bolognetti Fdn, Viale Regina Elena 291, I-00161 Rome, Italy
[3] Sapienza Univ Rome, Inst Mol Biol & Pathol, CNR, Piazzale Aldo Moro 5, I-00185 Rome, Italy
来源：
BIOLOGY OPEN | 2019年 / 8卷 / 02期
关键词：
Yeast; Respiration; Mitochondria; Mitochondrial DNA; Lysine-acetyltransferase Gcn5; GENE; YEAST; TRANSCRIPTION; ACETYLATION; RESPIRATION; IDENTIFICATION; LOCALIZATION; MUTATIONS; PROTEINS; STRESS;
D O I：
10.1242/bio.041244
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that GCN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype is related to a marked decrease in mtDNA content, which also involves the deletion of specific regions of the molecule. We also show that in wild-type mitochondria the Gcn5 protein is present in the mitoplasts, suggesting a new mitochondria! function independent from the SAGA complex and possibly a new function for this protein connecting epigenetics and metabolism.
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页数：9
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