Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis

被引：15

作者：

Bang, Sunghee ^{[1
]}

Shim, Sang Hee ^{[1
]}

机构：

[1] Duksung Womens Univ, Coll Pharm, Seoul 01369, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2020年 / 43卷 / 11期

关键词：

Natural products; Fungal secondary metabolites; β -Resorcylic acid lactones (RALs); Polyketides; PLANT-ASSOCIATED FUNGI; NATURAL-PRODUCTS; PARAPHAEOSPHAERIA-QUADRISEPTATA; HSP90; INHIBITORS; PROTEIN-KINASES; PAECILOMYCINS J; RADICICOL; ZEARALENONE; METABOLITES; ANALOGS;

D O I：

10.1007/s12272-020-01275-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

beta-Resorcylic acid lactones (RALs) are one of the major polyketides produced by fungi, and some of them have a diverse array of biological activities. Most RALs feature a 14-membered macrocyclic ring fused to beta-resorcylic acid (2,4-dihydroxybenzoic acid). In this review, more than 100 RAL-type of compounds are structurally classified into three groups; 14-membered RALs with 17R configuration, 14-membered RALs with 17S configuration, and benzopyranones/benzofuranones, and they are reviewed comprehensively in terms of chemistry, biological activities, and biosynthetic pathways.

引用

页码：1093 / 1113

页数：21

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