Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny

被引：6
|
作者：
Tsomartova, D. A. [1 ]
Yaglova, N. V. [1 ]
Yaglov, V. V. [1 ]
机构：
[1] Res Inst Human Morphol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 164卷 / 04期
关键词：
beta-catenin; Wnt signaling; adrenal; endocrine disruptors; DDT; MECHANISMS;
D O I：
10.1007/s10517-018-4019-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical beta-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.
引用
收藏
页码：493 / 496
页数：4
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  • [1] Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny
    D. A. Tsomartova
    N. V. Yaglova
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    [J]. Bulletin of Experimental Biology and Medicine, 2018, 164 : 493 - 496
  • [2] The Role of the Canonical Wnt-Signaling Pathway in Morphogenesis and Regeneration of the Adrenal Cortex in Rats Exposed to the Endocrine Disruptor Dichlorodiphenyltrichloroethane during Prenatal and Postnatal Development
    Yaglova, N. V.
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    [J]. BIOLOGY BULLETIN, 2019, 46 (01) : 74 - 81
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    [J]. Biology Bulletin, 2019, 46 : 74 - 81
  • [4] Morphological Changes in the Thymus of Newborn Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during the Prenatal Period
    N. V. Yaglova
    E. S. Tsomartova
    S. V. Nazimova
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    N. R. Pashina
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    [J]. Bulletin of Experimental Biology and Medicine, 2019, 167 : 297 - 299
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    Yaglova, N. V.
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    Nazimova, S. V.
    Obernikhin, S. S.
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    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2019, 167 (02) : 297 - 299
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