Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia

被引：67
|
作者：
Ohtsuki, T
Kitagawa, K
Yamagata, K
Mandai, K
Mabuchi, T
Matsushita, K
Yanagihara, T
Matsumoto, M
机构：
[1] OSAKA UNIV, SCH MED, DEPT MED 1, SUITA, OSAKA 565, JAPAN
[2] OSAKA UNIV, SCH MED, DEPT PHARMACOL, OSAKA, JAPAN
[3] OSAKA UNIV, SCH MED, DEPT NEUROL, OSAKA, JAPAN
来源：
BRAIN RESEARCH | 1996年 / 736卷 / 1-2期
关键词：
cyclooxygenase-2; cerebral ischemia; hippocampus;
D O I：
10.1016/0006-8993(96)00948-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the effect of brain ischemia on neuronal expression of cyclooxygenase-2 gene in the hippocampus. Transient forebrain ischemia was produced by occluding bilateral carotid arteries for 5 min in Mongolian gerbil. Northern blotting and in situ hybridization demonstrated that expression of cyclooxygenase-2 mRNA was transiently induced in the hippocampal neurons. Although future studies will be needed to clarify if induced cyclooxygenase-2 following ischemia is involved in neuronal damage or neuronal protection, selective cyclooxygenase-2 inhibitors may be a new therapeutical approach for the treatment of stroke.
引用
收藏
页码：353 / 356
页数：4
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