The chromatin remodeler complex ATRX-DAXX-H3.3 and telomere length in meningiomas

被引：5
|
作者：
Cavalcante, Stella G. [1 ]
Pereira, Benedito J. A. [1 ]
Lerario, Antonio M. [2 ]
Sola, Paula R. [1 ]
Oba-Shinjo, Sueli M. [1 ]
Marie, Suely K. N. [1 ]
机构：
[1] Univ Sao Paulo, Fac Med FMUSP, Dept Neurol, Lab Mol & Cellular Biol, LIM 15,Av Dr Arnaldo 455,4 Floor,Room 4110, Sao Paulo, SP, Brazil
[2] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Brehm Tower,Suite 5100,SPC 5714,1000 Wall St, Ann Arbor, MI 48109 USA
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 2021年 / 210卷
基金：
巴西圣保罗研究基金会;
关键词：
ATRX; DAXX; histone H3; 3; telomere length; meningiomas; CENTRAL-NERVOUS-SYSTEM; HISTONE H3.3; ATRX; DAXX; EXPRESSION; DNA; DEATH; SURVIVAL; COHESION; TUMORS;
D O I：
10.1016/j.clineuro.2021.106962
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
ATRX-DAXX-H3.3 chromatin remodeler complex is a well known epigenetic factor responsible for the heterochromatin maintenance and control. ATRX is an important nucleosome controller, especially in tandem repeat regions, and DAXX is a multi-function protein with particular role in histone H3.3 deposition due to its chaperone characteristic. Abnormalities in this complex have been associated with telomere dysfunction and consequently with activation of alternative lengthening of telomeres mechanism, genomic instability, and tumor progression in different types of cancer. However, the characterization of this complex is still incomplete in meningioma. We analyzed ATRX, DAXX and H3.3 expressions and the telomere length in a cohort of meningioma of different malignant grades. We observed ATRX upregulation at gene and protein levels in grade II/III meningiomas. A low variability of telomere length was observed in meningiomas across different ages and malignant grades, in contrast to the shortening of telomere length with aging in normal controls.
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页数：7
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