Comparison of Risks of Thromboembolism of Drospirenone-Containing and Nondrospirenone -Containing Combined Oral Contraceptive Use: A Meta-Analysis

被引：0
|
作者：
Zhang, Wan-Lin [1 ]
Dong, Zhe [2 ]
Zhang, Jun-Yan [3 ]
Lyu, Min-Zhi [4 ,5 ]
Zhang, Wei [6 ]
Huang, Jian-Lei [1 ]
Yang, Xin [7 ]
机构：
[1] Airforce Mil Med Univ, Tangdu Hosp, Dept Obstet & Gynecol, Reprod Med Ctr, Xian 710038, Peoples R China
[2] Peking Univ, Int Hosp, Dept Obstet & Gynecol, Beijing 102206, Peoples R China
[3] Bothwin Clin Study Consultant, Redmond, WA 98053 USA
[4] Fudan Univ, Zhongshan Hosp, Dept Biostat, Shanghai 200032, Peoples R China
[5] Fudan Univ, Ctr Evidence Based Med, Shanghai 200433, Peoples R China
[6] Fudan Univ, Sch Publ Hlth, Dept Biostat, Shanghai 200433, Peoples R China
[7] Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, 11th Xizhimen South St, Beijing 100044, Peoples R China
来源：
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE | 2021年 / 5卷 / 03期
关键词：
Arterial Thromboembolism; Combined Oral Contraceptives; Drospirenone; Venous Thromboembolism; VENOUS THROMBOEMBOLISM; HORMONAL CONTRACEPTIVES; NOMEGESTROL ACETATE; ACTIVE SURVEILLANCE; 24/4; REGIMEN; WOMEN; SAFETY; THROMBOSIS; EFFICACY; ETHINYLESTRADIOL/DROSPIRENONE;
D O I：
10.4103/2096-2924.324822
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.
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页码：154 / +
页数：10
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