Succinate semialdehyde dehydrogenase down-regulate γ-hydroxybutyric acid bindin deficiency does not sites in the mouse brain

被引：15

作者：

Mehta, AK

Gould, GG

Gupta, M

Carter, LP

Gibson, KM

Ticku, MK

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78229 USA

[2] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2006年 / 88卷 / 01期

关键词：

SSADH deficiency; GHB receptor; H-3]NCS-382; autoradiography; membrane homogenate binding;

D O I：

10.1016/j.ymgme.2005.11.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated whether succinate semialdehyde dehydrogenase deficiency alters gamma-hydroxybutyric acid (GHB) receptor characteristics due to elevation of GHB levels in the mouse brain. The membrane homogenate binding and quantitative autoradiography using [H-3]NCS-382 revealed no significant changes in the affinity (K-d), receptor density (B-max), or displacement potency (IC50) in various brain regions of Aldh5al(-/-) vs. Aldh5al(+/+) mice. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：86 / 89

页数：4

共 20 条

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