Polymorphisms in FTO and MAF Genes and Birth Weight, BMI, Ponderal Index, Weight Gain in a Large Cohort of Infants with a Birth Weight below 1500 Grams

被引:6
|
作者
Haller, Sebastian [1 ]
Spiegler, Juliane [1 ]
Hemmelmann, Claudia [2 ]
Kuester, Helmut [3 ]
Vochem, Matthias [4 ]
Moeller, Jens [5 ]
Mueller, Dirk [6 ]
Kribs, Angela [7 ]
Hoehn, Thomas [8 ]
Haertel, Christoph [1 ]
Herting, Egbert [1 ]
Goepel, Wolfgang [1 ]
机构
[1] Med Univ Lubeck, Dept Pediat, D-23538 Lubeck, Germany
[2] Med Univ Lubeck, Inst Med Biometry & Stat, D-23538 Lubeck, Germany
[3] Univ Gottingen, Dept Pediat, Gottingen, Germany
[4] Olgahosp Stuttgart, Stuttgart, Germany
[5] Childrens Hosp Saarbrucken, Saarbrucken, Germany
[6] Childrens Hosp Kassel, Kassel, Germany
[7] Univ Cologne, Dept Pediat, D-50931 Cologne, Germany
[8] Univ Dusseldorf, Dept Pediat, D-40225 Dusseldorf, Germany
来源
PLOS ONE | 2013年 / 8卷 / 06期
关键词
GENOME-WIDE ASSOCIATION; OBESITY; CHILDHOOD; VARIANT; MASS; AGE;
D O I
10.1371/journal.pone.0066331
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: The FTO gene, located on chromosome 16q12.2, and the MAF gene, located on chromosome 16q22-23, were identified as genes harboring common variants with an impact on obesity predisposition. We studied the association of common variants with birth weight, gain of body weight, body mass index (BMI), Ponderal index and relevant neonatal outcomes in a large German cohort of infants with a birth weight below 1500 grams. Methods: The single nucleotide polymorphisms rs9939609 (FTO gene) and rs1424233 (MAF gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study conducted in 15 neonatal intensive care units in Germany from September 2003 until January 2008. DNA samples were extracted from buccal swabs according to standard protocols. Results: 1946 infants were successfully genotyped at FTO and 2149 infants at MAF. Allele frequencies were not significantly different from other European cohorts. The polymorphisms were in Hardy-Weinberg equilibrium. The polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model. Discussion: Since an association of the polymorphisms with weight gain has been demonstrated in multiple populations, the lack of association in a population of preterm infants with regular tube feeding after birth and highly controlled feeding volumes provides evidence for the hypothesis that these polymorphisms affect food intake behavior and hunger rather than metabolism and energy consumption.
引用
收藏
页数:4
相关论文
共 50 条
  • [1] Major birth defects in infants with birth weight 501 to 1500 grams † 367
    Gautham K Suresh
    Jeffrey D Horbar
    [J]. Pediatric Research, 1998, 43 (Suppl 4) : 65 - 65
  • [2] Retinopathy of prematurity in infants with birth weight above 1500 grams
    Al-Essa, M
    Rashwan, N
    Al-Ajmi, M
    [J]. EAST AFRICAN MEDICAL JOURNAL, 2000, 77 (10) : 562 - 564
  • [3] HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams
    Göpel, W
    Fehlau, K
    Kohl, M
    Schultz, C
    Möller, J
    [J]. JOURNAL OF PERINATAL MEDICINE, 2002, 30 (02) : 176 - 178
  • [4] Maternal weight gain and correlation with birth weight infants
    Lumbanraja, S.
    Lutan, D.
    Usman, I.
    [J]. 13TH INTERNATIONAL EDUCATIONAL TECHNOLOGY CONFERENCE, 2013, 103 : 647 - 656
  • [5] DEVELOPMENTAL AND NEUROLOGIC OUTCOME OF INFANTS WITH BIRTH-WEIGHT UNDER 1500 GRAMS
    TEBERG, AJ
    WU, PYK
    HODGMAN, JE
    [J]. PEDIATRIC RESEARCH, 1973, 7 (04) : 424 - 424
  • [6] Interventional therapy in premature infants with a birth weight below 1500 g
    Kitzmueller, E.
    Marx, M.
    Greber-Platzer, S.
    Luckner, D.
    Salzer-Muhar, U.
    [J]. CLINICAL RESEARCH IN CARDIOLOGY, 2008, 97 (09) : 683 - 683
  • [7] Relationship Between Growth and Red Blood Cell Transfusions in a Birth Cohort of Low Birth Weight Infants <1500 grams
    Click, L.
    Skvarich, J.
    Castillejo, M.
    Matzick, T.
    Knezevic, A.
    Easley, K. A.
    Grier, K.
    Josephson, C.
    [J]. TRANSFUSION, 2011, 51 : 19A - 19A
  • [8] Growth of preterm very low birth weight infants discharged with weight of less than 1500grams
    Abdallah, Yaser
    Namiiro, Flavia
    Nankunda, Jolly
    Mugalu, Jamiru
    Vaucher, Yvonne
    [J]. BMC PEDIATRICS, 2021, 21 (01)
  • [9] Growth of preterm very low birth weight infants discharged with weight of less than 1500grams
    Yaser Abdallah
    Flavia Namiiro
    Jolly Nankunda
    Jamiru Mugalu
    Yvonne Vaucher
    [J]. BMC Pediatrics, 21
  • [10] Prepregnancy body mass index, gestational weight gain, and birth weight in the BRISA cohort
    Cutrim Propp Lima, Raina Jansen
    Lucena Batista, Rosangela Fernandes
    Costa Ribeiro, Marizelia Rodrigues
    Costa Ribeiro, Cecilia Claudia
    Ferreira Simoes, Vanda Maria
    Lima Neto, Pedro Martins
    Moura da Silva, Antonio Augusto
    Bettiol, Heloisa
    [J]. REVISTA DE SAUDE PUBLICA, 2018, 52