Cardiotrophin-1: A multifaceted cytokine

被引：46

作者：

Lopez-Yoldi, Miguel ^{[1
,2
]}

Moreno-Aliaga, Maria J. ^{[1
,2
,3
,4
]}

Bustos, Matilde ^{[5
]}

机构：

[1] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain

[2] Univ Navarra, Ctr Nutr Res, E-31080 Pamplona, Spain

[3] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain

[4] Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain

[5] Univ Navarra, CIMA Ctr Appl Med Res, Area Hepatol & Gene Therapy, E-31080 Pamplona, Spain

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 05期

关键词：

Cardiotrophin-1; Cytokines; IL-6; Cytoprotection; Metabolism; LEUKEMIA-INHIBITORY FACTOR; ACTIVATED PROTEIN-KINASE; INTERCELLULAR-ADHESION MOLECULE-1; INCREASED PLASMA CARDIOTROPHIN-1; GENETICALLY HYPERTENSIVE-RATS; NEUROTROPHIC FACTOR-RECEPTOR; LEPTIN-RESISTANT OBESITY; VEIN ENDOTHELIAL-CELLS; LEFT-VENTRICULAR MASS; CARDIAC MYOCYTES;

D O I：

10.1016/j.cytogfr.2015.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines that have pleiotropic functions on different tissues and cell types. Although many effects of CT-1 have been described on the heart, there is an extensive research showing important protective effects in other organs such as liver, kidney or nervous system. Recently, several studies have pointed out that CT-1 might also play a key role in the regulation of body weight and intermediate metabolism. This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：523 / 532

页数：10

共 50 条

[1] Cardiotrophin-1: a complex cytokine stimulated by ventricular stretch
Pemberton, C.
Raudsepp, S. D.
Cameron, V. A.
Yandle, T. G.
Richards, A. M.
[J]. EUROPEAN HEART JOURNAL, 2005, 26 : 66 - 66
[2] CARDIOTROPHIN-1 REVIEW
Stejskal, David
Ruzicka, Viktor
[J]. BIOMEDICAL PAPERS-OLOMOUC, 2008, 152 (01): : 9 - 19
[3] HEMODYNAMIC-EFFECTS OF CARDIOTROPHIN-1, A NEW CYTOKINE, IN CONSCIOUS RATS
YANG, RH
JIN, HK
PENNICA, D
WOOD, WI
PAONI, NF
[J]. CIRCULATION, 1995, 92 (08) : 2720 - 2720
[4] EXPRESSION CLONING OF CARDIOTROPHIN-1, A CYTOKINE THAT INDUCES CARDIAC MYOCYTE HYPERTROPHY
PENNICA, D
KING, KL
SHAW, KJ
LUIS, E
RULLAMAS, J
LUOH, SM
DARBONNE, WC
KNUTZON, DS
YEN, R
CHIEN, KR
BAKER, JB
WOOD, WI
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) : 1142 - 1146
[5] Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues
Latchman, DS
[J]. PHARMACOLOGY & THERAPEUTICS, 2000, 85 (01) : 29 - 37
[6] ROLE OF CARDIOTROPHIN-1 IN A CANINE MODEL OF ATRIAL FIBRILLATION AND THE EFFECT OF IRBESARTAN ON CARDIOTROPHIN-1
Han Hongya
Zhou Yujie
Bu Congya
Fang Zhe
Yan Zhenxian
Ma Hanying
Liu Xiaoli
[J]. HEART, 2011, 97 : A25 - A25
[7] Cardiotrophin-1, an antiinflammatory cytokine; is there a therapeutic role in orthotopic liver transplantation?
Fukuhara, Shinichi
Leitman, I. Michael
[J]. JOURNAL OF SURGICAL RESEARCH, 2013, 185 (01) : E63 - E65
[8] Cardiotrophin-1 in heart failure
Bristow, MR
Long, CS
[J]. CIRCULATION, 2002, 106 (12) : 1430 - 1432
[9] In vivo effects of cardiotrophin-1
Jin, HK
Yang, RH
Keller, GA
Ryan, A
Ko, A
Finkle, D
Swanson, TA
Li, W
Pennica, D
Wood, WI
Paoni, NF
[J]. CYTOKINE, 1996, 8 (12) : 920 - 926
[10] Atrial fibrillation and cardiotrophin-1
Altun, I.
Bilge, A. K.
Altun, I.
Guz, G.
Yilmaz, A.
Yildiz, C. E.
Polat, N.
Yilmaz, E.
Adalet, K.
[J]. EUROPEAN HEART JOURNAL, 2011, 32 : 473 - 473

← 1 2 3 4 5 →