Indole Synthesis via Rhodium Catalyzed Oxidative Coupling of Acetanilides and Internal Alkynes

被引：650
|
作者：
Stuart, David R. [1 ]
Bertrand-Laperle, Megan [1 ]
Burgess, Kevin M. N. [1 ]
Fagnou, Keith [1 ]
机构：
[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON, Canada
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 49期
关键词：
D O I：
10.1021/ja806955s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The oxidative synthesis of highly functionalized indoles from simple anilines and internal alkynes mediated by a rhodium(III) catalyst is described. Good yields are obtained for a variety of aniline substrates, and good regioselectivity is obtained for the more sterically accessible position when meta-substituted anilines are used. Symmetrical and unsymmetrical. alkynes react efficiently with high (> 40:1) C2/C3 regioselectivity when aryl/atkyl substituted alkynes are used.
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收藏
页码：16474 / +
页数：3
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