KLF5 functions in proliferation, differentiation, and apoptosis of chicken satellite cells

被引：5
|
作者：
Zhang, Xian-Xian [1 ]
Lian, Ting [1 ]
Ran, Jin-Shan [1 ]
Li, Zhi-Qiang [1 ]
Han, Shun-Shun [1 ]
Liu, Yi-Ping [1 ]
机构：
[1] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu Campus, Chengdu 611130, Sichuan, Peoples R China
来源：
3 BIOTECH | 2019年 / 9卷 / 06期
关键词：
KLF5; Chicken satellite cells; Proliferation; Differentiation; Apoptosis; KRUPPEL-LIKE FACTOR-5; TRANSCRIPTION FACTORS; EXPRESSION; SYNDECAN-4; REGULATOR;
D O I：
10.1007/s13205-019-1752-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
KLF5 is an important regulator of cell proliferation, differentiation, and apoptosis in mammals. Little is known about the function of KLF5 in the regulation of chicken. Hence, qPCR was used to detect the expression of KLF5 in different tissues of chicken. And chicken skeletal muscle satellite cells (SMSCs) were transfected KLF5-specific small interfering RNA (siRNA) to assay SMSCs' proliferation, differentiation, and apoptosis. The results showed that KLF5 expressed higher in skeletal muscle than in the other tissues of chicken. Knockdown of KLF5 significantly inhibited the differentiation and increased apoptosis of chicken SMSCs, but it had no significant effect on proliferation of SMSCs. These results indicate that KLF5 plays an essential role during myogenesis, which will affect muscle repair and muscle regeneration, and may ameliorate muscle aging or sarcopenia.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] KLF5 functions in proliferation, differentiation, and apoptosis of chicken satellite cells
    Xian-Xian Zhang
    Ting Lian
    Jin-Shan Ran
    Zhi-Qiang Li
    Shun-Shun Han
    Yi-Ping Liu
    3 Biotech, 2019, 9
  • [2] KLF4 and KLF5 are regulators of proliferation, differentiation, and apoptosis in esophageal cancer cells
    Yang, YZ
    Goldstein, BG
    Chao, HH
    Katz, J
    GASTROENTEROLOGY, 2005, 128 (04) : A602 - A602
  • [3] KLF4 and KLF5 regulate proliferation, apoptosis and invasion in Esophageal cancer cells
    Yang, YZ
    Goldstein, BG
    Chao, HH
    Katz, JP
    CANCER BIOLOGY & THERAPY, 2005, 4 (11) : 1216 - 1221
  • [4] Different Expression Patterns and Functions of Acetylated and Unacetylated Klf5 in the Proliferation and Differentiation of Prostatic Epithelial Cells
    Xing, Changsheng
    Fu, Xiaoying
    Sun, Xiaodong
    Guo, Peng
    Li, Mei
    Dong, Jin-Tang
    PLOS ONE, 2013, 8 (06):
  • [5] KLF5 induces apoptosis in colon cancer cells
    Marinaro, Joseph M.
    Bateman, Nicholas W.
    Black, Adrian R.
    CANCER RESEARCH, 2006, 66 (08)
  • [6] Klf5 acts as a differentiation switch from proliferation to fusion in myoblasts
    Akpulat, U.
    Yildiz, Y.
    Ozdemir-Saka, C.
    Akcay, D.
    Kocaefe, C.
    FEBS JOURNAL, 2016, 283 : 114 - 114
  • [7] KLF5 is essential for adipocyte differentiation
    Oishi, Y
    Manabe, I
    Tobe, K
    Shindo, T
    Tsushima, K
    Yamauchi, T
    Kadowaki, T
    Nagai, R
    CIRCULATION, 2004, 110 (17) : 244 - 244
  • [8] Klf4 and Klf5 play critical and complementary roles in esophageal epithelial proliferation and differentiation
    Yang, YZ
    Goldstein, BG
    Chao, HH
    Katz, JP
    GASTROENTEROLOGY, 2005, 128 (04) : A356 - A356
  • [9] miR-21-5p Regulates the Proliferation and Differentiation of Skeletal Muscle Satellite Cells by Targeting KLF3 in Chicken
    Zhang, Donghao
    Ran, Jinshan
    Li, Jingjing
    Yu, Chunlin
    Cui, Zhifu
    Amevor, Felix Kwame
    Wang, Yan
    Jiang, Xiaosong
    Qiu, Mohan
    Du, Huarui
    Zhu, Qing
    Yang, Chaowu
    Liu, Yiping
    GENES, 2021, 12 (06)
  • [10] KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
    Hui-jing Shi
    Jin-kun Wen
    Sui-bing Miao
    Yan Liu
    Bin Zheng
    Molecular and Cellular Biochemistry, 2012, 367 : 185 - 194
12345