Relationship between bone turnover biomarkers, mandibular bone mineral density, and systemic skeletal bone mineral density in premenopausal and postmenopausal Indian women

被引:21
|
作者
Makker, Annu [2 ,3 ]
Singh, Man Mohan [1 ,2 ]
Mishra, Geetanjali [2 ,4 ]
Singh, Balendra Pratap [5 ]
Jain, Girish Kumar [6 ]
Jadhav, Satyawan [6 ]
机构
[1] Saraswati Dent Coll & Hosp, Lucknow, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Endocrinol, Lucknow 226001, Uttar Pradesh, India
[3] CSM Med Univ, Postgrad Dept Pathol, Lucknow, Uttar Pradesh, India
[4] Univ Lucknow, Dept Zool, Lucknow 226007, Uttar Pradesh, India
[5] CSM Med Univ, Dept Prosthodont, Lucknow, Uttar Pradesh, India
[6] Cent Drug Res Inst, Div Pharmacokinet & Metab, Lucknow 226001, Uttar Pradesh, India
关键词
Mandibular bone mineral density; Systemic skeletal bone mineral density; Dual-energy x-ray absorptiometry; Bone turnover biomarkers; Menopause; Indian women; PANORAMIC RADIOGRAPHIC FINDINGS; BIOCHEMICAL MARKERS; TOOTH LOSS; OSTEOPOROSIS; ASSOCIATION; HORMONE; ROLES; TEETH; RISK; BODY;
D O I
10.1097/gme.0b013e31823dbbf7
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Postmenopausal osteoporosis is one of the most common metabolic bone disorders. Osteoporosis is reported to cause bone loss in the alveolar processes of maxilla and mandible, which provide bony framework for tooth anchorage. However, the association between systemic osteoporosis and oral health remains controversial. Available evidence suggests that Indian women have lower peak bone mass than their Western/other Asian counterparts. The present study evaluated the relationship between mandibular bone mineral density (mBMD), systemic skeletal BMD, and bone metabolism in premenopausal and postmenopausal Indian women. Methods: One hundred twenty-four premenopausal and 247 postmenopausal healthy women were included in the study. The BMD of the body of mandible, radius ultradistal, total hip, femur neck, and lateral spine were measured using dual-energy x-ray absorptiometry. Serum and urine biomarkers were determined using commercial kits. Results: Univariate regression analysis followed by stepwise multivariate regression analysis to obtain the best fit model demonstrated the BMD of radius ultradistal, serum inorganic phosphorus, estradiol, and sex hormone- binding globulin as significant predictors of mBMD in premenopausal women. The BMD of femur neck, serum ionized calcium, bone-specific alkaline phosphatase, osteocalcin, and urine total pyridinoline were significantly associated with mBMD in postmenopausal women. The significant association between mBMD and number of teeth present was observed in the whole group of premenopausal and postmenopausal women. Conclusions: Varied predictors of mBMD were observed in premenopausal and postmenopausal women. The results suggest that the screening for these biomarkers and serum ionized calcium should be useful (1) to assess the status of mBMD particularly in women requiring surgical dental intervention that include bone manipulation and (2) for early detection and management of women with the risk of developing osteoporosis.
引用
收藏
页码:642 / 649
页数:8
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