Discovery of potent and orally bioavailable phthalazinone Bradykinin B1 receptor antagonists for chronic pain

被引：0
|
作者：
Biswas, Kaustav
Peterkin, Tanya A. N.
Bryan, Marian C.
Arik, Leyla
Lehto, Sonya G.
Sun, Hong
Hsieh, Feng-Yin
Xu, Cen
Fremeau, Robert T.
Allen, Jennifer R.
机构：
[1] Amgen Inc, Dept Chem Res & Discovery, Thousand Oaks, CA 91320 USA
[2] Amgen Inc, Dept Pharmacokinet & Drug Metab, Thousand Oaks, CA 91320 USA
[3] Amgen Inc, Dept Neurosci, Thousand Oaks, CA 91320 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 240卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
7-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists
    Biswas, Kaustav
    Peterkin, Tanya A. N.
    Bryan, Marian C.
    Arik, Leyla
    Lehto, Sonya G.
    Sun, Hong
    Hsieh, Feng-Yin
    Xu, Cen
    Fremeau, Robert T.
    Allen, Jennifer R.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (20) : 7232 - 7246
  • [2] Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists
    Kuduk, Scott D.
    Di Marco, Christina N.
    Chang, Ronald K.
    Wood, Michael R.
    Schirripa, Kathy M.
    Kim, June J.
    Wai, Jenny M. C.
    DiPardo, Robert M.
    Murphy, Kathy L.
    Ransom, Richard W.
    Harrell, C. Meacham
    Reiss, Duane R.
    Holahan, Marie A.
    Cook, Jacquelynn
    Hess, J. Fred
    Sain, Nova
    Urban, Mark O.
    Tang, Cuyue
    Prueksaritanont, Thomayant
    Pettibone, Douglas J.
    Bock, Mark G.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (02) : 272 - 282
  • [3] THE THERAPEUTIC POTENTIAL OF BRADYKININ B1 RECEPTOR ANTAGONISTS IN CHRONIC PAIN
    Farkas, S.
    Eles, J.
    [J]. DRUGS OF THE FUTURE, 2011, 36 (04) : 301 - 319
  • [4] Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists
    Ward, Simon E.
    Eddershaw, Peter J.
    Scott, Claire M.
    Gordon, Laurie J.
    Lovell, Peter J.
    Moore, Susan H.
    Smith, Paul W.
    Starr, Kathryn R.
    Thewlis, Kevin M.
    Watson, Jeannette M.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (10) : 2887 - 2890
  • [5] From Bradykinin B2 Receptor Antagonists to Orally Active and Selective Bradykinin B1 Receptor Antagonists
    Barth, Martine
    Bondoux, Michel
    Luccarini, Jean-Michel
    Peyrou, Vincent
    Dodey, Pierre
    Pruneau, Didier
    Massardier, Christine
    Paquet, Jean-Luc
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (06) : 2574 - 2584
  • [6] Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists
    Chen, Jian Jeffrey
    Qian, Wenyuan
    Biswas, Kaustav
    Viswanadhan, Vellarkad N.
    Askew, Benny C.
    Hitchcock, Stephen
    Hungate, Randall W.
    Arik, Leyla
    Johnson, Eileen
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (16) : 4477 - 4481
  • [7] MEDI 455-Potent and orally bioavailable Bradykinin B1 antagonists based on a 5-pyrimidinyl cyclopropanecarboxamide core
    Wai, Jenny
    Anthony, Neville J.
    Di Marco, Christina Ng
    Feng, Dong-Mei
    Gomez, Robert P.
    Schirripa, Kathy
    Wood, Michael R.
    Murphy, Kathy L.
    Ransom, Richard W.
    Tang, Cuyue
    Prueksaritanont, Thomayant
    Pettibone, Douglas J.
    Freidinger, Roger M.
    Bock, Mark G.
    Kuduk, Scott D.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [8] Potent and orally bioavailable non-peptide antagonists at the human bradykinin B1 receptor based on a 2-alkylamino-5-sulfamoylbenzamide core
    Ritchie, TJ
    Dziadulewicz, EK
    Culshaw, AJ
    Müller, W
    Burgess, GM
    Bloomfield, GC
    Drake, GS
    Dunstan, AR
    Beattie, D
    Hughes, GA
    Ganju, P
    McIntyre, P
    Bevan, SJ
    Davis, C
    Yaqoob, M
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (19) : 4642 - 4644
  • [9] Chromenones as potent bradykinin B1 antagonists
    Bryan, Marian C.
    Biswas, Kaustav
    Peterkin, Tanya A. N.
    Rzasa, Robert M.
    Arik, Leyla
    Lehto, Sonya G.
    Sun, Hong
    Hsieh, Feng-Yin
    Xu, Cen
    Fremeau, Robert T.
    Allen, Jennifer R.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) : 619 - 622
  • [10] Aryl sulfones as novel Bradykinin B1 receptor antagonists for treatment of chronic pain
    Biswas, Kaustav
    Aya, Toshihiro
    Qian, Wenyuan
    Peterkin, Tanya A. N.
    Chen, Jian Jeffrey
    Human, Jason
    Hungate, Randall W.
    Kumar, Gondi
    Arik, Leyla
    Lester-Zeiner, Dianna
    Biddlecome, Gloria
    Manning, Barton H.
    Sun, Hong
    Dong, Hong
    Huang, Ming
    Loeloff, Richard
    Johnson, Eileen J.
    Askew, Benny C.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (17) : 4764 - 4769
12345