Regenerative Medicine: lessons from Mother Nature

被引：9

作者：

Naranjo, Juan Diego ^{[1
,2
]}

Scarritt, Michelle E. ^{[1
,2
]}

Huleihel, Luai ^{[1
,2
]}

Ravindra, Anjani ^{[1
,3
]}

Torres, Crisanto M. ^{[1
,2
]}

Badylak, Stephen F. ^{[1
,2
,4
]}

机构：

[1] McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA

[2] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15213 USA

[3] Childrens Hosp UPMC, Div Pediat Pulm Med Allergy & Immunol, Pittsburgh, PA 15224 USA

[4] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15213 USA

来源：

REGENERATIVE MEDICINE | 2016年 / 11卷 / 08期

关键词：

bioscaffolds; blastema; constructive remodeling; development; microenvironmental niche; regeneration; stem cell; tissue engineering; whole-organ engineering; PLURIPOTENT STEM-CELLS; EXTRACELLULAR-MATRIX SCAFFOLDS; SMALL-INTESTINAL SUBMUCOSA; OASIS WOUND MATRIX; MACROPHAGE PHENOTYPE; IMMUNE-RESPONSE; STROMAL CELLS; IN-VITRO; MUSCLE; THERAPY;

D O I：

10.2217/rme-2016-0111

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Regenerative medicine strategies for the restoration of functional tissue have evolved from the concept of ex vivo creation of engineered tissue toward the broader concept of in vivo induction of functional tissue reconstruction. Multidisciplinary approaches are being investigated to achieve this goal using evolutionarily conserved principles of stem cell biology, developmental biology and immunology, current methods of engineering and medicine. This evolution from ex vivo tissue engineering to the manipulation of fundamental in vivo tenets of development and regeneration has the potential to capitalize upon the incredibly complex and only partially understood ability of cells to adapt, proliferate, self-organize and differentiate into functional tissue.

引用

页码：767 / 775

页数：9

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