DRUG DISCOVERY Choosing your druggability battle

被引：1
|
作者：
Owen, Dafydd [1 ]
机构：
[1] Pfizer Med Design, Discovery Network Grp, Cambridge, MA 02139 USA
来源：
NATURE CHEMICAL BIOLOGY | 2019年 / 15卷 / 07期
关键词：
BROMODOMAIN;
D O I：
10.1038/s41589-019-0305-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The advent of PROTACs that degrade the entire protein target rather than simply inhibiting it bring druggable yet apparently non-functional binding sites into play for medicinal chemists to do their work.
引用
收藏
页码：652 / 653
页数：2
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