Microsatellite alterations in non-small cell lung cancer

被引：0
|
作者：
Petmitr, S
Nuchfaong, S
Chaksangchaichot, P
Pongstaporn, W
Sutinont, P
Limsila, T
Punyarit, P
机构：
[1] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok 10400, Thailand
[2] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pathol, Bangkok 10400, Thailand
[3] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Surg, Bangkok 10400, Thailand
[4] Pramongkutklao Coll Med, Dept Pathol, Bangkok, Thailand
[5] Rangsit Univ, Fac Med Technol, Pathum Thani, Thailand
来源：
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2002年 / 21卷 / 01期
关键词：
non-small cell lung cancer; tobacco smoking; microsatellite DNA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genetic alterations at 12 dinucleotide repeat loci located on human chromosomes 2, 3, 12, and 17 have been analyzed in non-small cell lung cancer from Thai patients. Seventeen out of 30 cases (57%) harbored the microsatellite alterations. Of the 30 cases, 19 patients had a history of tobacco smoking, of whom 14 (74%) were in the group with microsatellite alterations, whereas 3 out of 11 non-smokers (26%) had these alterations. The frequency of microsatellite alterations among smokers was significantly higher than it was in non-smokers (P = 0.01 Fisher's exact test; odds ratio; 7.47).
引用
收藏
页码：31 / 35
页数：5
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