Stochastic Simulation Service: Bridging the Gap between the Computational Expert and the Biologist

被引:35
|
作者
Drawert, Brian [1 ]
Hellander, Andreas [2 ]
Bales, Ben [3 ]
Banerjee, Debjani [1 ]
Bellesia, Giovanni [1 ]
Daigle, Bernie J., Jr. [4 ,5 ]
Douglas, Geoffrey [1 ]
Gu, Mengyuan [1 ]
Gupta, Anand [1 ]
Hellander, Stefan [1 ]
Horuk, Chris [1 ]
Nath, Dibyendu [1 ]
Takkar, Aviral [1 ]
Wu, Sheng [1 ]
Lotstedt, Per [2 ]
Krintz, Chandra [1 ]
Petzold, Linda R. [1 ,3 ]
机构
[1] Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA
[2] Uppsala Univ, Div Comp Sci, Dept Informat Technol, Uppsala, Sweden
[3] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA
[4] Univ Memphis, Dept Biol Sci, Memphis, TN 38152 USA
[5] Univ Memphis, Dept Comp Sci, Memphis, TN 38152 USA
基金
美国国家科学基金会;
关键词
REACTION-DIFFUSION PROCESSES; SYSTEMS; MECHANISMS; PROTEINS; SBML;
D O I
10.1371/journal.pcbi.1005220
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present StochSS: Stochastic Simulation as a Service, an integrated development environment for modeling and simulation of both deterministic and discrete stochastic biochemical systems in up to three dimensions. An easy to use graphical user interface enables researchers to quickly develop and simulate a biological model on a desktop or laptop, which can then be expanded to incorporate increasing levels of complexity. StochSS features state-of-the-art simulation engines. As the demand for computational power increases, StochSS can seamlessly scale computing resources in the cloud. In addition, StochSS can be deployed as a multi-user software environment where collaborators share computational resources and exchange models via a public model repository. We demonstrate the capabilities and ease of use of StochSS with an example of model development and simulation at increasing levels of complexity.
引用
收藏
页数:15
相关论文
共 50 条
  • [1] Bridging the Gap Between Simulation and Reality
    Hanna, Josiah P.
    [J]. AAMAS'17: PROCEEDINGS OF THE 16TH INTERNATIONAL CONFERENCE ON AUTONOMOUS AGENTS AND MULTIAGENT SYSTEMS, 2017, : 1834 - 1835
  • [2] New computational simulation techniques for nanosystems: Bridging the gap
    Maguire, John
    Benedict, Mark D.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
  • [3] Bridging the Gap between Stochastic Gradient MCMC and Stochastic Optimization
    Chen, Changyou
    Carlson, David
    Gan, Zhe
    Li, Chunyuan
    Carin, Lawrence
    [J]. ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 51, 2016, 51 : 1051 - 1060
  • [4] Bridging the gap between service description models in service matchmaking
    Fernandez, Alberto
    Cong, Zijie
    Balta, Analay
    [J]. MULTIAGENT AND GRID SYSTEMS, 2012, 8 (01) : 83 - 103
  • [5] Bridging the Gap Between Computational Photography and Visual Recognition
    VidalMata, Rosaura G.
    Banerjee, Sreya
    RichardWebster, Brandon
    Albright, Michael
    Davalos, Pedro
    McCloskey, Scott
    Miller, Ben
    Tambo, Asong
    Ghosh, Sushobhan
    Nagesh, Sudarshan
    Yuan, Ye
    Hu, Yueyu
    Wu, Junru
    Yang, Wenhan
    Zhang, Xiaoshuai
    Liu, Jiaying
    Wang, Zhangyang
    Chen, Hwann-Tzong
    Huang, Tzu-Wei
    Chin, Wen-Chi
    Li, Yi-Chun
    Lababidi, Mahmoud
    Otto, Charles
    Scheirer, Walter J.
    [J]. IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2021, 43 (12) : 4272 - 4290
  • [6] Towards Bridging a Gap between Simulation and Experiment
    Marepalli, Prabhakar
    Li, Fengyuan Thomas
    Clark, Jason V.
    [J]. NANOTECHNOLOGY 2011: ELECTRONICS, DEVICES, FABRICATION, MEMS, FLUIDICS AND COMPUTATIONAL, NSTI-NANOTECH 2011, VOL 2, 2011, : 627 - 630
  • [7] Bridging the gap between expert and novice users for video search
    Martin Halvey
    Joemon M. Jose
    [J]. International Journal of Multimedia Information Retrieval, 2012, 1 (1) : 17 - 29
  • [8] Bridging the gap between expert and novice users for video search
    Halvey, Martin
    Jose, Joemon M.
    [J]. INTERNATIONAL JOURNAL OF MULTIMEDIA INFORMATION RETRIEVAL, 2012, 1 (01) : 17 - 29
  • [9] Bridging the gap between service provision and customer expectations
    McKnight, Susan
    [J]. PERFORMANCE MEASUREMENT AND METRICS, 2009, 10 (02) : 79 - 93
  • [10] Bridging the gap between fair simulation and trace inclusion
    Kesten, Y
    Piterman, N
    Pnueli, A
    [J]. INFORMATION AND COMPUTATION, 2005, 200 (01) : 35 - 61