Efficient Synthesis of Spirooxindole-Fused 3-Thiazoline Derivatives by a One-Pot Asinger-Type Reaction

被引：11
|
作者：
Rainoldi, Giulia [1 ]
Begnini, Fabio [1 ]
Silvani, Alessandra [1 ]
Lesma, Giordano [1 ]
机构：
[1] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy
来源：
SYNLETT | 2016年 / 27卷 / 20期
关键词：
thiazoline; oxindole; spiro compounds; Asinger; multicomponent reactions; Ugi-Joullie reaction; MULTICOMPONENT REACTIONS; ANTICANCER AGENTS; FACILE SYNTHESIS; THIAZOLINE; PEPTIDOMIMETICS; INHIBITORS; ISATIN;
D O I：
10.1055/s-0036-1589286
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, three-component reaction has been developed and successfully employed for the synthesis of biologically relevant, highly functionalized spirooxindole-fused 3-thiazoline derivatives. Starting from ammonia, three mercapto carbonyl components and a series of substituted isatins, products were obtained in good yields (24 examples), by following a simple and rapid protocol. The obtained thiazolines proved to be optimal substrates for further transformations, including the three-component Ugi-Joullie reaction.
引用
收藏
页码：2831 / 2835
页数：5
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