The Role of Inflammation in Age-Related Macular Degeneration

被引：120
|
作者：
Tan, Wei [1 ,2 ]
Zou, Jingling [1 ,2 ]
Yoshida, Shigeo [3 ]
Jiang, Bing [1 ,2 ]
Zhou, Yedi [1 ,2 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Ophthalmol, Changsha 410011, Hunan, Peoples R China
[2] Hunan Clin Res Ctr Ophthalm Dis, Changsha 410011, Hunan, Peoples R China
[3] Kurume Univ, Dept Ophthalmol, Sch Med, Kurume, Fukuoka 8300011, Japan
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 16卷 / 15期
基金：
中国国家自然科学基金;
关键词：
inflammation; cytokine; leukocyte; age-related macular degeneration; PIGMENT EPITHELIAL-CELLS; C-REACTIVE PROTEIN; ANTI-VEGF THERAPY; CHOROIDAL NEOVASCULARIZATION; AQUEOUS-HUMOR; DENDRITIC CELLS; T-CELLS; MESENCHYMAL TRANSITION; CIRCULATING MONOCYTES; BRUCHS MEMBRANE;
D O I：
10.7150/ijbs.49890
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Age-related macular degeneration (AMD) is a blinding eye disease which incidence gradually increases with age. Inflammation participates in AMD pathogenesis, including choroidal neovascularization and geographic atrophy. It is also a kind of self-protective regulation from injury for the eyes. In this review, we described inflammation in AMD pathogenesis, summarized the roles played by inflammation-related cytokines, including pro-inflammatory and anti-inflammatory cytokines, as well as leukocytes (macrophages, dendritic cells, neutrophils, T lymphocytes and B lymphocytes) in the innate or adaptive immunity in AMD. Possible clinical applications such as potential diagnostic biomarkers and anti-inflammatory therapies were also discussed. This review overviews the inflammation as a target of novel effective therapies in treating AMD.
引用
收藏
页码：2989 / 3001
页数：13
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