Sulfamethoxazole Susceptibility of Mycobacterium tuberculosis Isolates from HIV-Infected Ugandan Adults with Tuberculosis Taking Trimethoprim-Sulfamethoxazole Prophylaxis

被引：5
|
作者：
Ogwang, Sam [1 ,2 ]
Good, Caryn E. [3 ]
Okware, Brenda [1 ]
Nsereko, Mary [1 ]
Jacobs, Michael R. [3 ]
Boom, W. Henry [4 ]
Bark, Charles M. [5 ]
机构：
[1] Uganda Case Western Reserve Univ Res Collaborat, Kampala, Uganda
[2] Joint Clin Res Ctr, Kampala, Uganda
[3] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, TB Res Unit, Cleveland, OH 44106 USA
[5] Metrol Hlth Med Ctr, Cleveland, OH USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 09期
基金：
美国国家卫生研究院;
关键词：
COMBINATION;
D O I：
10.1128/AAC.01101-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40 Mycobacterium tuberculosis isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of <= 38.4 mu g/ml.
引用
收藏
页码：5844 / 5846
页数：3
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