Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity

被引：27
|
作者：
Thrush, A. Brianne [1 ]
Dent, Robert [2 ]
McPherson, Ruth [3 ]
Harper, Mary-Ellen [1 ]
机构：
[1] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada
[2] Ottawa Hosp, Weight Management Clin, Ottawa, ON, Canada
[3] Univ Ottawa, Inst Heart, Ottawa, ON K1H 8M5, Canada
来源：
FEBS JOURNAL | 2013年 / 280卷 / 20期
关键词：
diet resistance; mitochondria; obesity; oxidative phosphorylation; proton leak; uncoupling; weight loss; BROWN ADIPOSE-TISSUE; FATTY-ACID OXIDATION; RESTING ENERGY-EXPENDITURE; OXYGEN SPECIES PRODUCTION; BASAL METABOLIC-RATE; NONEXERCISE ACTIVITY THERMOGENESIS; SPONTANEOUS PHYSICAL-ACTIVITY; INSULIN SIGNAL-TRANSDUCTION; SYMPATHETIC-NERVOUS-SYSTEM; TERM CALORIE RESTRICTION;
D O I：
10.1111/febs.12399
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity-related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success.
引用
收藏
页码：5015 / 5029
页数：15
相关论文
共 50 条
  • [1] Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control
    Dantas, Wagner S.
    Zunica, Elizabeth R. M.
    Heintz, Elizabeth C.
    Vandanmagsar, Bolormaa
    Floyd, Z. Elizabeth
    Yu, Yongmei
    Fujioka, Hisashi
    Hoppel, Charles L.
    Belmont, Kathryn P.
    Axelrod, Christopher L.
    Kirwan, John P.
    [J]. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2022, 13 (03) : 1821 - 1836
  • [2] Mitochondrial uncoupling as a target in the treatment of obesity
    Costford, Sheila
    Gowing, Adrienne
    Harper, Mary-Ellen
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (06): : 671 - 678
  • [3] Mitochondrial Uncoupling Decreases Sarcopenic Obesity By Activation of Skeletal Muscle Mitochondrial Quality Control and Attenuated ER Stress
    Dantas, Wagner S.
    Zunica, Elizabeth R. M.
    Heintz, Elizabeth C.
    Hoppel, Charles L.
    Axelrod, Christopher L.
    Kirwan, John P.
    [J]. FASEB JOURNAL, 2022, 36
  • [4] Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity
    Anja Voigt
    Yvonne Katterle
    Melanie Kahle
    Reinhart Kluge
    Annette Schürmann
    Hans-Georg Joost
    Susanne Klaus
    [J]. Genes & Nutrition, 2015, 10
  • [5] Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity
    Voigt, Anja
    Katterle, Yvonne
    Kahle, Melanie
    Kluge, Reinhart
    Schuermann, Annette
    Joost, Hans-Georg
    Klaus, Susanne
    [J]. GENES AND NUTRITION, 2015, 10 (06): : 1 - 11
  • [6] Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity
    Bombek, Lidija Krizancic
    Cater, Masa
    [J]. METABOLITES, 2022, 12 (03)
  • [7] Mitochondrial uncoupling in mice skeletal muscle in cancer cachexia
    Psychogios, Nikolaos
    Constantinou, Caterina
    Righi, Valerie
    Fontes de Oliveira, Cibely C.
    Shestov, Alexander A.
    Mintzopoulos, Dionyssios
    Busquets, Silvia
    Lopez-Soriano, Francisco J.
    He, Jianxin
    Milot, Sylvain
    Mindrinos, Michael N.
    Lepine, Francois
    Rahme, Laurence G.
    Argiles, Josep M.
    Tzika, Aria A.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 : S53 - S53
  • [8] Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure
    van den Berg, Sjoerd A. A.
    Lichtenbelt, Wouter van Marken
    van Dijk, Ko Willems
    Schrauwen, Patrick
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2011, 14 (03): : 243 - 249
  • [9] Mitochondrial uncoupling proteins and energetics in human heart and skeletal muscle
    Johnson, A.
    Holloway, C.
    Edwards, L.
    Heather, L.
    Cochlin, L.
    Taggart, D.
    Ratnatunga, C.
    Pillai, R.
    Evans, R.
    Clarke, K.
    [J]. ANAESTHESIA, 2011, 66 (01) : 69 - 69
  • [10] Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model
    Tzika, A. Aria
    Fontes-Oliveira, Cibely Cristine
    Shestov, Alexander A.
    Constantinou, Caterina
    Psychogios, Nikolaos
    Righi, Valeria
    Mintzopoulos, Dionyssios
    Busquets, Silvia
    Lopez-Soriano, Francisco J.
    Milot, Sylvain
    Lepine, Francois
    Mindrinos, Michael N.
    Rahme, Laurence G.
    Argiles, Josep M.
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 43 (03) : 886 - 894
12345