Long non-coding RNA-422 acts as a tumor suppressor in colorectal cancer

被引：28
|
作者：
Shao, Qianwen [1 ]
Xu, Jing [2 ]
Deng, Rong [3 ]
Wei, Wei [3 ]
Zhou, Bing [3 ]
Yue, Chao [3 ]
Zhu, Miaoling [4 ]
Huang, Xingen [5 ]
Zhu, Haitao [3 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Dept Oncol, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Genet Testing Ctr, Dept Oncol, Nanjing 210009, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Canc Hosp, Canc Res Inst, Jiangsu Canc Hosp,Colorectal Canc Ctr,Dept Gen Su, Nanjing 210009, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Canc Hosp, Dept Pathol, Nanjing 210029, Jiangsu, Peoples R China
[5] Nanjing Med Univ, Canc Hosp, Dept Med, 42 Baiziting Rd, Nanjing 210029, Jiangsu, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 495卷 / 01期
关键词：
lncRNA-422; Colorectal cancer; Proliferation; Apoptosis; PI3K/AKT/mTOR; CELL-PROLIFERATION; RNA MALAT1; METASTASIS; EXPRESSION; PATHWAY; ACTIVATION; PROGNOSIS; CCAT1;
D O I：
10.1016/j.bbrc.2017.10.076
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Colorectal cancer (CRC) is one of the most frequent cancer in numerous of countries worldwidely. The initiation and progression of CRC is an extremely complex process, and have been suggested a correlation with Long non-coding RNAs (lncRNAs). Our results showed that lncRNA-422(ENST00000415820) significantly downregulated in the tissues and serum of CRC patients, and is closely associated with the poor prognosis. Then gain or loss of lncRNA-422 models in SW480 and SW620cells were established. The results showed that lncRNA-422 overexpression inhibited cell proliferation, migration, and invasion. Knockdown of lncRNA-422 promoted tumorigensis. Western blot and qRT-PCR were performed to examine the activity of the PI3K/AKT/mTOR pathway in CRC cells after alternation of lncRNA-422. Results showed that lncRNA-422 acts as a tumor suppressor by PI3K/AKT/mTOR pathway in CRC (C) 2017 Published by Elsevier Inc.
引用
收藏
页码：539 / 545
页数：7
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