Assessment of the Role of 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Fungal Infections in Adults

被引：30

作者：

Lamoth, F. ^{[1
,2
,3
]}

Akan, H. ^{[4
]}

Andes, D. ^{[5
]}

Cruciani, M. ^{[6
]}

Marchetti, O. ^{[1
,2
,7
]}

Ostrosky-Zeichner, L. ^{[8
]}

Racil, Z. ^{[9
]}

Clancy, C. J. ^{[10
]}

机构：

[1] Lausanne Univ Hosp, Infect Dis Serv, Lausanne, Switzerland

[2] Univ Lausanne, Lausanne, Switzerland

[3] Lausanne Univ Hosp, Inst Microbiol, Lausanne, Switzerland

[4] Ankara Univ, Fac Med, Hematol Clin Res Unit, Cebeci Campus, Ankara, Turkey

[5] Univ Wisconsin, Dept Med & Microbiol & Immunol, Madison, WI USA

[6] G Fracastoro Hosp, Infect Dis Unit, San Bonifacio, Verona, Italy

[7] Ensemble Hosp La Cote, Dept Med, Morges, Switzerland

[8] McGovern Med Sch, Div Infect Dis, Houston, TX USA

[9] Inst Hematol & Blood Transfus, Prague, Czech Republic

[10] Univ Pittsburgh, Div Infect Dis, Pittsburgh, PA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷

关键词：

beta-glucan; invasive aspergillosis; invasive candidiasis; hematologic cancer; intensive care; BETA-D-GLUCAN; INTENSIVE-CARE-UNIT; BRONCHOALVEOLAR LAVAGE FLUID; EMPIRICAL ANTIFUNGAL THERAPY; CRITICALLY-ILL PATIENTS; SERUM 1,3-BETA-D-GLUCAN; HIGH-RISK; HEMATOLOGICAL MALIGNANCIES; PULMONARY ASPERGILLOSIS; TRICHOSPORON FUNGEMIA;

D O I：

10.1093/cid/ciaa1943

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Detection of 1,3-beta-d-glucan (BDG) in serum has been evaluated for its inclusion as a mycological criterion of invasive fungal infections (IFI) according to EORTC and Mycoses Study Group (MSG) definitions. BDG testing may be useful for the diagnosis of both invasive aspergillosis and invasive candidiasis, when interpreted in conjunction with other clinical/radiological signs and microbiological markers of IFI. However, its performance and utility vary according to patient population (hematologic cancer patients, solid-organ transplant recipients, intensive care unit patients) and pretest likelihood of IFI. The objectives of this article are to provide a systematic review of the performance of BDG testing and to assess recommendations for its use and interpretation in different clinical settings.

引用

页码：S102 / S108

页数：7

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