A genome scan for quantitative trait loci affecting milk production in Norwegian dairy cattle

被引:82
|
作者
Olsen, HG [1 ]
Gomez-Raya, L
Våge, DI
Olsaker, I
Klungland, H
Svendsen, M
Ådnoy, T
Sabry, A
Klemetsdal, G
Schulman, N
Krämer, W
Thaller, G
Ronningen, K
Lien, S
机构
[1] Agr Univ Norway, Dept Anim Sci, N-1432 As, Norway
[2] IRTA, Ctr UdL, Dept Anim Prod, Lleida 25198, Spain
[3] Norwegian Sch Vet Sci, N-0033 Oslo, Norway
[4] Agr Res Ctr MTT, Jokioinen 31600, Finland
[5] Tech Univ Munich, Chair Anim Breeding, D-85380 Freising Weihenstephan, Germany
关键词
quantitative trait loci; milk; cattle;
D O I
10.3168/jds.S0022-0302(02)74400-7
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
An autosomal genome scan for quantitative trait loci (QTL) affecting milk production traits was carried out on the Norwegian Dairy Cattle population. Six half-sibling families with a total of 285 sons organized according to a granddaughter design were analyzed by a multiple marker regression method. Suggestive QTL for one or several of the five milk traits (milk yield i protein percentage, protein yield, fat percentage and fat yield). were detected on chromosomes 3, 5, 6, 11, 13, M and 20. Among these results, the findings on chromosomes 3, 6, and 20 are highly supported by literature. The most convincing result was found close to marker FBN9 on chromosome 6, where a QTL was detected with alleles that cause a marked reduction in both protein and fat percentages and an increase in milk yield. The results for fat and protein percentage were highly significant even after accounting for multiple testing across the genome. Using bootstrapping, a 95% confidence interval for the position of the QTL for the percentage traits on chromosome 6 was estimated to 16 cM.
引用
收藏
页码:3124 / 3130
页数:7
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