Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

被引：12

作者：

Peluso, S ^{[1
]}

Dumy, P ^{[1
]}

Eggleston, IM ^{[1
]}

Garrouste, P ^{[1
]}

Mutter, M ^{[1
]}

机构：

[1] UNIV LAUSANNE,INST ORGAN CHEM,BCH DORIGNY,CH-1015 LAUSANNE,SWITZERLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 21期

关键词：

D O I：

10.1016/S0040-4020(97)00408-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic. (C) 1997 Elsevier Science Ltd.

引用

页码：7231 / 7236

页数：6

共 6 条

[1] Protein Mimetics (TASP) by Sequential Condensation of Peptide Loops to an Immobilised Topological Template
Peluso, S.
Dumy, P.
Eggleston, I. M.
Garrouste, P.
Tetrahedron, 53 (21):
[2] THE TASP CONCEPT - MIMETICS OF PEPTIDE LIGANDS, PROTEIN SURFACES AND FOLDING UNITS
TUCHSCHERER, G
DOMER, B
SILA, U
KAMBER, B
MUTTER, M
TETRAHEDRON, 1993, 49 (17) : 3559 - 3575
[3] Evolutionary principles for generating protein mimetics: Directed assembly of peptide loops on topological templates
Banfi, D
Mandal, B
Mutter, M
Patiny, L
ACTA BIOCHIMICA POLONICA, 2001, 48 (04) : 1105 - 1107
[4] TEMPLATE ASSEMBLED SYNTHETIC PROTEINS - CONDENSATION OF A MULTIFUNCTIONAL PEPTIDE TO A TOPOLOGICAL TEMPLATE VIA CHEMOSELECTIVE LIGATION
TUCHSCHERER, G
TETRAHEDRON LETTERS, 1993, 34 (52) : 8419 - 8422
[5] SYNTHESIS OF A 4-HELIX BUNDLE-LIKE TEMPLATE-ASSEMBLED SYNTHETIC PROTEIN (TASP) BY CONDENSATION OF A PROTECTED PEPTIDE ON A CONFORMATIONALLY CONSTRAINED CYCLIC CARRIER
ERNEST, I
VUILLEUMIER, S
FRITZ, H
MUTTER, M
TETRAHEDRON LETTERS, 1990, 31 (28) : 4015 - 4018
[6] Preparation of peptide thioesters using Fmoc-solid-phase peptide synthesis and its application to the construction of a template-assembled synthetic protein (TASP)
Futaki, S
Sogawa, K
Maruyama, J
Asahara, T
Niwa, M
Hojo, H
TETRAHEDRON LETTERS, 1997, 38 (35) : 6237 - 6240

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