Imbalanced Distribution of GM Immunoglobulin Allotypes According to the Clinical Presentation of Plasmodium falciparum Malaria in Beninese Children

被引：17
|
作者：
Migot-Nabias, Florence [1 ,2 ]
Noukpo, Julien M. [1 ,2 ]
Guitard, Evelyne [3 ,4 ]
Doritchamou, Justin [1 ,2 ]
Garcia, Andre [1 ,2 ]
Dugoujon, Jean-Michel [3 ,4 ]
机构：
[1] IRD, UR 010, Fac Sci Sante, Cotonou, Benin
[2] Inst Sci Biomed Appl, Cotonou, Benin
[3] CNRS, FRE 2960, Lab Anthropol, Toulouse, France
[4] Univ Toulouse 3, F-31062 Toulouse, France
来源：
JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 12期
关键词：
D O I：
10.1086/593210
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Selection pressure exerted by pathogens contributes to the persistence of polymorphisms in GM and KM allotypes, which are antigenic determinants of immunoglobulins. This study investigated the impact of GM and KM allotypes on the clinical response to Plasmodium falciparum infection among Beninese children, including 65 with severe malaria, 37 with uncomplicated malaria, and 53 with asymptomatic carriage. An inverse relationship was found between the GM5,6,13,14; 1,17 phenotype and uncomplicated malaria. Genetic markers implicated in the composition and activity of immunoglobulins may be associated with the genetic control of both malaria infection and morbidity.
引用
收藏
页码：1892 / 1895
页数：4
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