T cell antigen-receptor signal transduction

被引：205
|
作者：
van Leeuwen, JEM [1 ]
Samelson, LE [1 ]
机构：
[1] NCI, Lab Cellular & Mol Biol, NIH, Bethesda, MD 20892 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期
关键词：
D O I：
10.1016/S0952-7915(99)80040-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on. LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-C gamma 1-Ca2+ signalling pathways, TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effecters of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation.
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页码：242 / 248
页数：7
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