An efficient synthesis of [15N]-carbazole from [15N]-aniline

被引：5
|
作者：
Peterson, MA [1 ]
Nilsson, BL [1 ]
机构：
[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA
来源：
SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 21期
关键词：
D O I：
10.1080/00397919908086022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A reaction sequence involving ortho-lithiation of [N-15]-(tert-Butoxycarbonyl)aniline, quenching with Bu3SnCl, palladium catalyzed coupling with bromobenzene, and deprotection provides efficient access to [N-15]-2-aminobiphenyl (4). Compound 4 is converted to [N-15]-carbazole via diazotization, treatment with NaN3, and heating to promote intramolecular nitrene insertion.
引用
收藏
页码：3821 / 3827
页数：7
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