Inactivation of H-type and L-type bovine spongiform encephalopathy following recommended autoclave decontamination procedures

被引：3
|
作者：
Chapman, Gail E. [1 ,4 ]
Lockey, Richard [1 ,5 ]
Beck, Katy E. [1 ]
Vickery, Chris [1 ]
Arnold, Mark [1 ]
Thorne, Leigh [1 ]
Thorne, Jemma K. [1 ]
Walker, Sarah R. [1 ]
van Keulen, Lucien [2 ]
Casalone, Cristina [3 ]
Griffiths, Peter C. [1 ]
Simmons, Marion M. [1 ]
Terry, Linda A. [1 ]
Spiropoulos, John [1 ]
机构：
[1] Anim & Plant Hlth Agcy APHA, Weybridge KT15 3NB, Surrey, England
[2] Wageningen UR, Wageningen Biovet Res, Lelystad, Netherlands
[3] Ist Zooprofilatt Sperimentale Piemonte, Liguria & Valle Aosta Sede Cent Torino, Turin, Italy
[4] Univ Glasgow, Sch Vet Med, Div Pathol Publ Hlth & Dis Invest, Glasgow, Lanark, Scotland
[5] Univ Southampton, Safety & Occupat Hlth, Southampton, Hants, England
来源：
TRANSBOUNDARY AND EMERGING DISEASES | 2020年 / 67卷 / 05期
关键词：
bovine spongiform encephalopathy; H-type; inactivation; L-type; transmissible spongiform encephalopathie; SCRAPIE; BSE; MICE; THERMOSTABILITY; TRANSMISSION; STRAINS; AGENT;
D O I：
10.1111/tbed.13513
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The resistance of H-type and L-type BSE prions to autoclaving under EU regulation conditions for specified risk material is unknown. We employed transgenic mouse (bovinized line tg1896) bioassay to assess the efficacy of such decontamination on L- and H-type BSE. For each source, titre calculation was based on the comparison of incubation period and attack rate prior to and after decontamination. The infectious titre of L-type BSE was reduced by at least 9.40 log(10)and of H-type BSE by at least 3.94 log(10). In fact, no infectivity was detected for L-type or H-type BSE post-inactivation even at a 10(-1)dilution.
引用
收藏
页码：1872 / 1878
页数：7
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