Identification of potential crucial genes associated with vasculogenic mimicry in human osteosarcoma based on gene expression profile

被引：8
|
作者：
Yao, N. [1 ,2 ]
Ren, K. [3 ]
Gu, X. J. [4 ]
Wu, S. J. [5 ]
Shi, X. [5 ]
Chang, Q. [3 ]
Li, Y. G. [3 ]
Gao, Z. X. [3 ]
Jin, Q. M. [1 ,2 ]
Zhang, J. [1 ,2 ]
Wang, C. [3 ]
Zhou, J. [1 ,2 ,6 ]
机构：
[1] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China
[2] Jiangsu Prov Acad Tradit Chinese Med, Lab Translat Med, Nanjing 210028, Jiangsu, Peoples R China
[3] Southeast Univ, Zhongda Hosp, Dept Orthoped, Nanjing 210009, Jiangsu, Peoples R China
[4] Dalian Jiaotong Univ, Sch Environm & Chem Engn, Inst Biotechnol, Dalian 116028, Liaoning, Peoples R China
[5] Nanjing Univ, Jinling Hosp, Sch Med, Dept Orthoped, Nanjing 210002, Jiangsu, Peoples R China
[6] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing 211198, Jiangsu, Peoples R China
来源：
NEOPLASMA | 2020年 / 67卷 / 02期
基金：
中国国家自然科学基金;
关键词：
osteosarcoma; microarray analysis; neoplasm metastasis; TUMOR-CELL PLASTICITY; MELANOMA-CELLS; IN-VITRO; PATHWAYS; PROMOTES; INVASION; GROWTH; CANCER;
D O I：
10.4149/neo_2019_190414N329
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We previously reported the presence of vasculogenic mimicry (VM) in human osteosarcoma. However, the mechanistic basis of osteosarcoma VM remains unclear. Three hundred eighty-one upregulated differentially expressed genes (DEGs) and 526 downregulated DEGs between human osteosarcoma cell line 143B and HOS cell exposed to Matrigel were screened out by microarray. GO categories such as "cell adhesion", "angiogenesis" were enriched in 143B group. PATHWAY analysis showed enriched TGF-beta, Wnt and VEGF signaling pathway in 143B group. The hub gene ITGA2 in signal-network of DEGs exhibited pro-VM and pro-metastasis effect. Our study provides fundamental data for further studies regarding molecules involved in osteosarcoma VM.
引用
收藏
页码：286 / +
页数：11
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