Anti-diabetic Effect of FriedelanTriterpenoids in Streptozotocin Induced Diabetic Rat

被引：0
|
作者：
Mandal, Amitava [1 ]
Das, Vaskar [2 ]
Ghosh, Pranab [1 ]
Ghosh, Shilpi [2 ]
机构：
[1] Univ N Bengal, Dept Chem, Nat Prod & Polymer Chem Lab, Darjeeling 734013, W Bengal, India
[2] Univ N Bengal, Dept Biotechnol, Darjeeling 734013, W Bengal, India
来源：
NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 10期
关键词：
Anti-diabetic; Steptozotocin; Triterpenoid; Cerin; Anti-oxidants; TISSUE ANTIOXIDANTS; QUERCETIN; ESTER;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We herein report the anti-diabetic effect of the natural friedelan tritepenoid, 4-oxa-3, 4-secofriedelan (cerin), isolated from cork-tissue of Quercus suber L. and its oxygenated derivative, 4-oxa-3, 4-secofriedelan-3-oic acid (cerin(o lambda)) in streptozotocin (STZ)-induced diabetic rat. Male Sprague Dawley rats were randomized into four groups: non-diabetic control (Group I), STZ-induced diabetic rats (Group II), STZ-induced diabetic rats treated with cerin (Group III), and STZ-induced diabetic rats treated with cerin(o lambda) (Group IV). Administration of cerin(o lambda) (3mg/kg) and cerin(o lambda) (3mg/kg) orally to STZ-diabetic rats for three weeks improved the body weight, reduced serum glucose level and activities of alkaline phosphatase, acid phosphatase, glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase, and restored liver antioxidant status.
引用
收藏
页码：1683 / 1686
页数：4
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