Prognostic value of carbonic anhydrase IX expression in penile squamous cell carcinoma: A pilot study

被引:3
|
作者
Zhu, Yao [1 ,3 ]
Zhou, Xiao-Yan [2 ,3 ]
Yao, Xu-Dong [1 ,3 ]
Zhang, Shi-Lin [1 ,3 ]
Dai, Bo [1 ,3 ]
Zhang, Hai-Liang [1 ,3 ]
Shen, Yi-Jun [1 ,3 ]
Ye, Ding-Wei [1 ,3 ]
机构
[1] Fudan Univ, Dept Urol, Shanghai Canc Ctr, Shanghai 200433, Peoples R China
[2] Fudan Univ, Dept Pathol, Shanghai Canc Ctr, Shanghai 200433, Peoples R China
[3] Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai 200433, Peoples R China
关键词
Penile neoplasms; Cell hypoxia; Carbonic anhydrase; Immunohistochemistry; Lymphatic metastasis; Survival analysis; Prognosis; INTRINSIC MARKER; NUCLEAR ANTIGEN; POOR-PROGNOSIS; HYPOXIA; CANCER; PROTEIN; KI-67; P53; RELEVANCE; GENE;
D O I
10.1016/j.urolonc.2011.04.011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: To determine whether carbonic anhydrase IX (CA IX) has prognostic value of lymph node metastases and cancer-specific survival in penile squamous cell carcinoma treated with surgery. Materials and methods: CA IX expression was detected in the primary disease of 73 penile cancer patients using the method of immunohistochemistry. The expression levels of CA IX were categorized into 2 groups according to the cutoff of 10% of positively stained tumor cells. Associations between CA IX expression and clinicopathologic characteristics, immunoreactivity of p53 and Ki-67, and outcomes were analyzed. Results: High CA IX expression was observed in 31(42.5%) of cases. CA IX expression was not associated with patient age, T stage, grade, lymphovascular invasion, and Ki-67 expression, but was associated with p53 expression (P = 0.015). Both univariate and multivariate analysis failed to show CA IX expression was a statistically significant predictor of lymph node metastases and cancer-specific survival. Conclusions: Immunohistochemical expression of CA IX did not associate with lymph node metastases and cancer-specific survival in penile squamous cell carcinoma. A panel of prognostic markers that reflect the characteristic of tumor cell and organ microenvironment may be more suitable for prognostication in penile cancer. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:706 / 711
页数:6
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