Evaluating tumor-suppressor gene combinations

被引：2
|
作者：
Kim, James [1 ,2 ,3 ]
Minna, John D. [1 ,2 ,4 ]
机构：
[1] Univ Texas Southwestern, Dept Internal Med, Div Hematol Oncol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[3] Univ Texas Southwestern, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
[4] Univ Texas Southwestern, Dept Pharmacol, Dallas, TX USA
来源：
NATURE GENETICS | 2018年 / 50卷 / 04期
关键词：
CELL LUNG-CANCER; IN-VIVO; ADENOCARCINOMA; LANDSCAPE;
D O I：
10.1038/s41588-018-0095-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR-Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.
引用
收藏
页码：480 / 482
页数：4
相关论文
共 50 条
  • [1] Evaluating tumor-suppressor gene combinations
    James Kim
    John D. Minna
    Nature Genetics, 2018, 50 : 480 - 482
  • [2] BLID: A Novel Tumor-Suppressor Gene
    Yu, Xin
    Li, Zheng
    ONCOLOGY RESEARCH, 2015, 22 (5-6) : 333 - 338
  • [3] TUMOR-SUPPRESSOR GENE CONCEPT OF CARCINOGENESIS
    WUNDERLICH, V
    RAJEWSKY, MF
    LANCET, 1995, 345 (8964): : 1570 - 1571
  • [4] P53 - A TUMOR-SUPPRESSOR GENE
    WUSTROW, TPU
    HNO, 1993, 41 (05) : A12 - A13
  • [5] CLONING OF A PUTATIVE MENINGIOMA TUMOR-SUPPRESSOR GENE
    RIEGMAN, PHJ
    DEPREZ, KHL
    GROEN, N
    KORTENHORST, U
    HAGEMEIJER, A
    VANDRUNEN, E
    BOOTSMA, D
    MENON, A
    KLEY, N
    SEIZINGER, BR
    DEJONG, P
    ZWARTHOFF, EC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 193 - 193
  • [6] CLONING OF A PUTATIVE MENINGIOMA TUMOR-SUPPRESSOR GENE
    ZWARTHOFF, EC
    RIEGMAN, PHJ
    GROEN, NA
    KORTENHORST, UL
    HAGEMEIJER, A
    VANDRUNEN, E
    BOOTSMA, D
    MENON, A
    KLEY, N
    SEIZINGER, BR
    DEJONG, P
    DEPREZ, RHL
    AMERICAN JOURNAL OF HUMAN GENETICS, 1993, 53 (03) : 164 - 164
  • [7] A SILENCER ELEMENT IN THE RETINOBLASTOMA TUMOR-SUPPRESSOR GENE
    OHTANIFUJITA, N
    FUJITA, T
    TAKAHASHI, R
    ROBBINS, PD
    DRYJA, TP
    SAKAI, T
    ONCOGENE, 1994, 9 (06) : 1703 - 1711
  • [8] THE P53 TUMOR-SUPPRESSOR GENE
    LEVINE, AJ
    NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (20): : 1350 - 1352
  • [9] Cloning and sequencing of tumor-suppressor gene FHIT
    Huang, Zhan
    Zhu, Fan
    Jiang, Da-he
    Li, Wen-xin
    Wuhan Daxue Xuebao/Journal of Wuhan University, 1999, 45 (04): : 480 - 484
  • [10] MOLECULAR CHARACTERIZATION OF A CHORIOCARCINOMA TUMOR-SUPPRESSOR GENE
    VOLAND, JR
    BECKER, C
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 204 - 204
12345