Targeted delivery of β-glucosidase-loaded magnetic nanoparticles: effect of external magnetic field duration and intensity

被引：5
|
作者：
Zhou, Jie [1 ,2 ]
Hou, Jing [1 ,2 ]
Liu, Yunlong [3 ]
Rao, Jun [2 ,4 ]
机构：
[1] Hubei Prov Hosp Tradit Chinese Med, Dept Urol, Wuhan, Hubei, Peoples R China
[2] Hubei Prov Acad Tradit Chinese Med, Dept Urol, Wuhan, Hubei, Peoples R China
[3] Zhengzhou Univ, Dept Urol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China
[4] Hubei Prov Hosp Tradit Chinese Med, Clin Lab, Wuhan, Hubei, Peoples R China
来源：
NANOMEDICINE | 2020年 / 15卷 / 21期
基金：
中国国家自然科学基金;
关键词：
beta-glucosidase; enzyme activity; magnetic field duration and intensity; magnetic nanoparticles; targeted delivery; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; IN-VIVO; TUMOR; BIODISTRIBUTION; ACCUMULATION; PEPTIDES; THERAPY; SIZE;
D O I：
10.2217/nnm-2020-0186
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim:The effect of applied magnetic field duration and intensity on the delivery of beta-glucosidase-loaded magnetic nanoparticles was evaluated.Materials & methods:The prepared beta-glucosidase-loaded magnetic nanoparticles were targeted to subcutaneous tumors with an external magnetic field. Iron concentration and enzyme activity in tumor tissue were analyzed via electron spin resonance detection, Prussian blue staining and enzyme activity measurement.Results:The increase in magnetic nanoparticles quantity and enzyme activity in tumor tissue was not synchronous with the magnetic targeting duration. In addition, accumulation of magnetic nanoparticles and the increase in enzyme activity were not synchronous with the magnetic field intensity.Conclusion:The results suggested that appropriate magnetic field conditions should be considered for targeted delivery of bioactivity proteins based on magnetic nanoparticles.
引用
收藏
页码：2029 / 2040
页数：12
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