Effect of sublingual administration of interferon-α on the immune response to influenza vaccination in institutionalized elderly individuals

被引：15
|
作者：
Launay, Odile [2 ,3 ,4 ]
Grabar, Sophie [2 ,5 ]
Bloch, Frederic [6 ]
Desaint, Corinne [3 ,4 ]
Jegou, David [5 ]
Lallemand, Christophe [1 ]
Erickson, Robert [7 ]
Lebon, Pierre [8 ]
Tovey, Michael G. [1 ]
机构：
[1] Inst Andre Lwoff, CNRS, Lab Oncol Virale, FRE 2937, F-94801 Villejuif, France
[2] Univ Paris 05, Fac Med, Paris, France
[3] Grp Hosp Cochin St Vincent de Paul, AP HP, CIC Vaccinol Cochin Pasteur CIC BT505, Paris, France
[4] INSERM, CIC Vaccinol Cochin Pasteur, Paris, France
[5] Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Biostat, Paris, France
[6] Grp Hosp Broca La Rochefoucauld, AP HP, Serv Gerontol 1, Paris, France
[7] Orakine Ltd, Galway Technol Ctr, Galway, Ireland
[8] Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Virol, Paris, France
来源：
VACCINE | 2008年 / 26卷 / 32期
关键词：
influenza vaccine; interferon; the elderly;
D O I：
10.1016/j.vaccine.2008.05.035
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A randomized double-blind placebo-controlled study was conducted to determine the effect of sublingual administration of IFN alpha on the immune response to influenza vaccination in elderly institutionalized individuals. Sublingual administration of 10 million IU of IFN alpha immediately prior to vaccination, reduced the geometric mean haemagglutination inhibitory (HAI) and IgG2 circulating antibody titers, and the secretory IgA (sIgA) response in saliva, to the New York strain of influenza A virus, 21 days post-vaccination, without detectable drug-related local or systemic toxicity. IFN treatment did not inhibit the immune response to the other components of the vaccine; the New Caledonia strain of influenza A virus, or the Jiangsu strain of influenza B virus. At the dose tested sublingual administration of IFN alpha reduces the immune response to influenza vaccination in elderly institutionalized individuals. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4073 / 4079
页数：7
相关论文
共 50 条
  • [1] Immune response to influenza vaccination in healthy elderly subjects:: Evaluation of interferon-γ production
    Gardner, EM
    Willis, JM
    Murasko, DM
    FASEB JOURNAL, 2005, 19 (04): : A408 - A408
  • [2] Immune response to influenza vaccination in institutionalized elderly: effect on different T-cell subsets
    McElhaney, JE
    Gravenstein, S
    Upshaw, CM
    Hooton, JW
    Krause, P
    Drinka, P
    VACCINE, 1998, 16 (04) : 403 - 409
  • [3] Immune response to influenza vaccination in an elderly population
    Brydak, LB
    Machala, M
    Mysliwska, J
    Mysliwski, A
    Trzonkowski, P
    JOURNAL OF CLINICAL IMMUNOLOGY, 2003, 23 (03) : 214 - 222
  • [4] Immune Response to Influenza Vaccination in an Elderly Population
    Lidia B. Brydak
    Magdalena Machała
    Jolanta Myśliwska
    Andrzej Myśliwski
    Piotr Trzonkowski
    Journal of Clinical Immunology, 2003, 23 : 214 - 222
  • [5] Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects
    Fulop, T
    Wagner, JR
    Khalil, A
    Weber, J
    Trottier, L
    Payette, H
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1999, 54 (02): : M59 - M64
  • [6] The influence of sequential annual vaccination and of DHEA administration on the efficacy of the immune response to influenza Vaccine in the elderly
    Ben-Yehuda, A
    Danenberg, HD
    Zakay-Rones, Z
    Gross, DJ
    Friedman, G
    MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 102 (2-3) : 299 - 306
  • [7] Immune response to influenza vaccination in a large healthy elderly population
    Bernstein, E
    Kaye, D
    Abrutyn, E
    Gross, P
    Dorfman, M
    Murasko, DM
    VACCINE, 1999, 17 (01) : 82 - 94
  • [8] LACTOBACILLUS IN JELLY ENHANCES THE EFFECT OF INFLUENZA VACCINATION IN ELDERLY INDIVIDUALS
    Akatsu, Hiroyasu
    Arakawa, Kazuyuki
    Yamamoto, Takayuki
    Kanematsu, Takayoshi
    Matsukawa, Noriyuki
    Ohara, Hirotaka
    Maruyama, Mitsuo
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2013, 61 (10) : 1828 - 1830
  • [9] Negative effect on immune response of repeated influenza vaccination and waning effectiveness in interseason for elderly people
    Sugishita, Yoshiyuki
    Nakayama, Tetsuo
    Sugawara, Tamie
    Ohkusa, Yasushi
    VACCINE, 2020, 38 (21) : 3759 - 3765
  • [10] Immune response to influenza vaccination in the elderly is altered by chronic medication use
    Agarwal, Divyansh
    Schmader, Kenneth E.
    Kossenkov, Andrew, V
    Doyle, Susan
    Kurupati, Raj
    Ertl, Hildegund C. F.
    IMMUNITY & AGEING, 2018, 15
12345