Synthesis of 4-Alkenyl Benzoxazoles via Pd-catalyzed ortho C-H Functionalization of 2-Amidophenols

被引：14
|
作者：
Panda, Niranjan [1 ]
Sahoo, Kanchanbala [1 ]
机构：
[1] Natl Inst Technol Rourkela, Dept Chem, Rourkela 769008, Odisha, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 03期
关键词：
C-H activation; Benzoxazole; Pd-catalysis; C-H alkenylation; 2-amidophenol; INTRAMOLECULAR O-ARYLATION; ONE-POT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; COPPER; 2-ARYLBENZOXAZOLES; ACTIVATION; OLEFINATION; ANNULATION; BENZOTHIAZOLES; NANOPARTICLES;
D O I：
10.1002/adsc.201801272
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A one-pot direct transformation to remotely C-H alkene functionalized 2-aryl benzoxazoles from the reaction of amidophenol and electronically deficient olefin was reported. Control experiments confirm that the Pd-catalyzed regioselective C-H activation/alkenylation occurs at the first step by leading to ortho-alkenylated amidophenol; which subsequently underwent tandem intramolecular annulation to afford C4-alkenylated 2-arylbenzoxazole derivatives.
引用
收藏
页码：617 / 627
页数：11
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