Maternal immune activation in neurodevelopmental disorders

被引：93

作者：

Solek, Cynthia M. ^{[1
]}

Farooqi, Nasr ^{[1
]}

Verly, Myriam ^{[1
]}

Lim, Tony K. ^{[1
]}

Ruthazer, Edward S. ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

来源：

DEVELOPMENTAL DYNAMICS | 2018年 / 247卷 / 04期

基金：

加拿大健康研究院;

关键词：

neurodevelopmental disorders; maternal immune activation; autism spectrum disorder; schizophrenia; microglia; animal models; DORSOLATERAL PREFRONTAL CORTEX; AUTISM SPECTRUM DISORDERS; SCHIZOPHRENIA-LIKE ALTERATIONS; DEPRESSION-LIKE BEHAVIORS; NEURAL PROGENITOR CELLS; NECROSIS-FACTOR-ALPHA; PRENATAL EXPOSURE; MICROGLIAL ACTIVATION; VIRAL-INFECTION; PREPULSE INHIBITION;

D O I：

10.1002/dvdy.24612

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588-619, 2018. (c) 2017 Wiley Periodicals, Inc.

引用

页码：588 / 619

页数：32

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