IL-18: a suggested target for immunomodulation in chikungunya virus infection

被引：4
|
作者：
Chirathaworn, Chintana [1 ,2 ]
Chansaenroj, Jira [2 ]
Pongsuchart, Pornsuri [2 ]
Poovorawan, Yong [2 ]
机构：
[1] Chulalongkorn Univ, Fac Med, Dept Microbiol, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Dept Pediat, Bangkok 10330, Thailand
来源：
ARCHIVES OF VIROLOGY | 2021年 / 166卷 / 01期
关键词：
PATHOGENESIS; INTERLEUKIN-6; OUTBREAK; RANTES;
D O I：
10.1007/s00705-020-04849-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Chronic joint pain is the most common pathology found in chikungunya virus (CHIKV)-infected patients. Eight cytokines were compared in CHIKV patients with and without joint pain. IL-4 and IL-13 levels were significantly lower in patients with joint pain (p= 0.006 andp< 0.0001, respectively). IL-18 levels were higher in the group of patients with joint pain (p< 0.0001) and were significantly higher on days 3 and 4 after onset (p= 0.0012 andp= 0.003, respectively). Moreover, TNF-alpha levels were significantly higher in patients with joint pain on day 3 (p= 0.028). This study demonstrated that cytokines, particularly IL-18, may be candidates for immunomodulation.
引用
收藏
页码：219 / 223
页数：5
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