Tracking RNA polymerase, one step at a time

被引：11

作者：

Vassylyev, DG ^{[1
]}

Artsimovitch, I

机构：

[1] Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA

[2] Univ Alabama, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

来源：

CELL | 2005年 / 123卷 / 06期

关键词：

D O I：

10.1016/j.cell.2005.11.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the structural analysis of transcription has attained atomic resolution, techniques to manipulate single molecules involved in transcription have lagged behind. A recent paper in Nature by Abbondanzieri et al. (2005) closes this gap. This study finds that individual molecules of bacterial RNA polymerase move in single base-pair steps and concludes that RNA polymerase acts as a Brownian ratchet that is driven forward by the binding of incoming nucleoside triphosphates.

引用

页码：977 / 979

页数：3

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