Central Nervous System Prophylaxis in Non-Hodgkin Lymphoma: Who, What, and When?

被引：16

作者：

Cheah, Chan Yoon ^{[1
]}

Seymour, John F. ^{[2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[2] Peter MacCallum Canc Ctr, Dept Hematol, East Melbourne, Vic 8006, Australia

来源：

CURRENT ONCOLOGY REPORTS | 2015年 / 17卷 / 06期

关键词：

Central nervous system relapse; Non-Hodgkin lymphoma; Diffuse large B cell lymphoma; Mantle cell lymphoma; Risk stratification; Prognosis; Therapy; Intrathecal chemotherapy; Methotrexate; B-CELL LYMPHOMA; SPINAL-CORD COMPRESSION; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; PRIMARY EFFUSION LYMPHOMA; DOUBLE-HIT LYMPHOMA; RISK-FACTORS; PROGNOSTIC-FACTORS; CNS PROPHYLAXIS; INTRATHECAL CHEMOTHERAPY; PLASMABLASTIC LYMPHOMA;

D O I：

10.1007/s11912-015-0450-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary central nervous system (CNS) progression in patients with non-Hodgkin lymphoma (NHL) is associated with a particularly poor prognosis. In this review, we summarize and critically evaluate the current literature to guide the practicing clinician in estimating CNS relapse risk in order to select individual patients who may benefit from CNS prophylaxis, covering histologic subtype, anatomic location, and molecular and clinical factors. We summarize the data regarding different prophylaxis strategies used and provide our recommendation regarding who should receive it, what they should receive, and when it should be administered.

引用

页数：11

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