Benzylarylation of N-AllyI Anilines: Synthesis of Benzylated Indolines

被引：25

作者：

Huang, Wenzhong ^{[1
]}

Li, Xiulan ^{[1
]}

Song, Xuemei ^{[1
]}

Luo, Qing ^{[1
]}

Li, Yanping ^{[1
]}

Dong, Ying ^{[2
]}

Liang, Deqiang ^{[1
,3
]}

Wang, Baoling ^{[1
,3
]}

机构：

[1] Kunming Univ, Dept Chem, Kunming 650214, Yunnan, Peoples R China

[2] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China

[3] Yunnan Engn Technol Res Ctr Plast Films, Kunming 650214, Yunnan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; HIGHLY EFFICIENT ACCESS; FREE DIRECT ALKYLATION; C(SP(3))-H BONDS; OXIDATIVE CYCLIZATION; TOLUENE DERIVATIVES; ACTIVATED ALKYNES; FUNCTIONALIZATION; CATALYSIS; SP(3);

D O I：

10.1021/acs.joc.9b00237

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented benzylic C-H functionalization of methyl arenes across unactivated alkenes is presented. In the presence of MnCl2 center dot 4H(2)O and di-tert-butyl peroxide, N-allyl anilines underwent benzylation/cyclization cascade to give benzylated indolines, which are a previously unmet synthetic goal. This protocol features simple operation, broad substrate scope, and great exo selectivity.

引用

页码：6072 / 6083

页数：12

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