Enantioselective construction of sterically hindered tertiary α-aryl ketones: a catalytic asymmetric synthesis of isoflavanones

被引：29
|
作者：
Carroll, Michael P. [1 ]
Mueller-Bunz, Helge [1 ]
Guiry, Patrick J. [1 ]
机构：
[1] Univ Coll Dublin, Ctr Synth & Chem Biol, Sch Chem & Chem Biol, Dublin 4, Ireland
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 90期
关键词：
CROSS-COUPLINGS; ALLYLIC ALKYLATION; DECARBOXYLATIVE ALLYLATION; ARYLATION; ORGANOLEAD; ACIDITIES; ESTERS;
D O I：
10.1039/c2cc36452b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the catalytic asymmetric alpha-arylation of ketones bearing very sterically hindered aryl rings has been developed. This reaction occurs under mild conditions, in short reaction times and has been applied to the first catalytic asymmetric synthesis of isoflavanones.
引用
收藏
页码：11142 / 11144
页数：3
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