Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement

被引：136
|
作者：
Hallifax, D [1 ]
Houston, JB [1 ]
机构：
[1] Univ Manchester, Sch Pharm & Pharm Sci, Ctr Appl Pharmacokinet Res, Manchester M13 9PL, Lancs, England
来源：
DRUG METABOLISM AND DISPOSITION | 2006年 / 34卷 / 04期
关键词：
D O I：
10.1124/dmd.105.007658
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：724 / 726
页数：3
相关论文
共 16 条
  • [1] Response to "Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement"
    Austin, RP
    Barton, P
    Riley, RJ
    [J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (04) : 727 - 727
  • [2] Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement (vol 34, pg 724, 2006)
    Hallifax, D
    Houston, JB
    [J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (06) : 1078 - 1078
  • [3] Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes
    Sykes, Matthew J.
    Sorich, Michael J.
    Miners, John O.
    [J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2006, 46 (06) : 2661 - 2673
  • [4] Structure-Based Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes
    Li, Haiyan
    Sun, Jin
    Sui, Xiaofan
    Yan, Zhongtian
    Sun, Yinghua
    Liu, Xiaohong
    Wang, Yongjun
    He, Zhonggui
    [J]. AAPS JOURNAL, 2009, 11 (02): : 364 - 370
  • [5] Structure-Based Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes
    Haiyan Li
    Jin Sun
    Xiaofan Sui
    Zhongtian Yan
    Yinghua Sun
    Xiaohong Liu
    Yongjun Wang
    Zhonggui He
    [J]. The AAPS Journal, 2009, 11 : 364 - 370
  • [6] A Fragment-Based Approach for the Computational Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes
    Nair, Pramod C.
    McKinnon, Ross A.
    Miners, John O.
    [J]. DRUG METABOLISM AND DISPOSITION, 2016, 44 (11) : 1794 - 1798
  • [7] Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology
    Wood, F. L.
    Houston, J. B.
    Hallifax, D.
    [J]. DRUG METABOLISM AND DISPOSITION, 2017, 45 (11) : 1178 - 1188
  • [8] BENEFIT-RISK ASSESSMENT OF INVESTIGATIONAL DRUGS - CURRENT METHODOLOGY, LIMITATIONS, AND ALTERNATIVE APPROACHES
    COCCHETTO, DM
    NARDI, RV
    [J]. PHARMACOTHERAPY, 1986, 6 (06): : 286 - 303
  • [9] Current state of the art in HPLC methodology for lipophilicity assessment of basic drugs. A review
    Giaginis, Costas
    Tsantili-Kakoulidou, Anna
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2008, 31 (01) : 79 - 96
  • [10] Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes
    Obach, RS
    [J]. DRUG METABOLISM AND DISPOSITION, 1999, 27 (11) : 1350 - 1359
12