Structure-based drug design exploiting dynamic combinatorial chemistry to identify novel inhibitors for the aspartic protease endothiapepsin

被引:0
|
作者
Hirsch, Anna K. H. [1 ]
机构
[1] Univ Groningen, Stratingh Inst Chem, Groningen, Netherlands
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
443-COMP
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry
    Mondal, Milon
    Radeva, Nedyalka
    Koester, Helene
    Park, Ahyoung
    Potamitis, Constantinos
    Zervou, Maria
    Klebe, Gerhard
    Hirsch, Anna K. H.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (12) : 3259 - 3263
  • [2] Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin
    Mondal, Milon
    Groothuis, Daphne E.
    Hirsch, Anna K. H.
    [J]. MEDCHEMCOMM, 2015, 6 (07) : 1267 - 1271
  • [3] Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin
    Hartman, Alwin M.
    Mondal, Milon
    Radeva, Nedyalka
    Klebe, Gerhard
    Hirsch, Anna K. H.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (08): : 19184 - 19194
  • [4] Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry
    Mondal, Milon
    Radeva, Nedyalka
    Fanlo-Virgos, Hugo
    Otto, Sijbren
    Klebe, Gerhard
    Hirsch, Anna K. H.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (32) : 9422 - 9426
  • [5] Structure-based thermodynamic design of peptide ligands:: Application to peptide inhibitors of the aspartic protease endothiapepsin
    Luque, I
    Gömez, J
    Semo, N
    Freire, E
    [J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1998, 30 (01): : 74 - 85
  • [6] Structure-based drug design: Combinatorial chemistry and molecular modeling
    Kirkpatrick, DL
    Watson, S
    Ulhaq, S
    [J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 1999, 2 (04) : 211 - 221
  • [7] Combining structure-based drug design with combinatorial chemistry.
    Roe, DC
    Kick, EK
    Skillman, AG
    Liu, G
    Ellman, JA
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U688 - U688
  • [8] Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin
    Mondal, Milon
    Unver, M. Yagiz
    Pal, Asish
    Bakker, Matthijs
    Berrier, Stephan P.
    Hirsch, Anna K. H.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (42) : 14826 - 14830
  • [9] Structure-based drug design of HIV protease inhibitors.
    Navia, MA
    Tung, RD
    Chaturvedi, PR
    Rao, BG
    Partaledis, JA
    Kim, EE
    [J]. FASEB JOURNAL, 1996, 10 (06): : 2436 - 2436
  • [10] THE INTEGRATION OF STRUCTURE-BASED DRUG DESIGN & COMBINATORIAL CHEMISTRY FOR EFFICIENT DRUG DISCOVERY
    Salemme, F. Raymond
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C4 - C4