Genotoxic Impurities in Pharmaceutical Manufacturing: Sources, Regulations, and Mitigation

被引：143
|
作者：
Szekely, Gyorgy [1 ]
Amores de Sousa, Miriam C. [2 ,3 ]
Gil, Marco [4 ]
Ferreira, Frederico Castelo [2 ,3 ]
Heggie, William [4 ]
机构：
[1] Univ Manchester, Sch Chem Engn & Analyt Sci, Manchester M13 9PL, Lancs, England
[2] Univ Lisbon, Inst Super Tecn, Dept Bioengn, P-1049001 Lisbon, Portugal
[3] Univ Lisbon, iBB, Dept Bioengn, P-1049001 Lisbon, Portugal
[4] Hov FarmaCiencia SA, R&D, P-2674506 Loures, Portugal
来源：
CHEMICAL REVIEWS | 2015年 / 115卷 / 16期
关键词：
ORGANIC-SOLVENT NANOFILTRATION; SOLID-PHASE SYNTHESIS; MOLECULARLY IMPRINTED POLYMERS; TOXICOLOGICAL CONCERN CONCEPT; HIV PROTEASE INHIBITORS; LARGE-SCALE SYNTHESIS; EFFICIENT SYNTHESIS; IN-VITRO; ANTIBACTERIAL ACTIVITY; BATCH CRYSTALLIZATION;
D O I：
10.1021/cr300095f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：8182 / 8229
页数：48
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