A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals

被引:17
|
作者
Lei, Zuhai [2 ]
Zeng, Zhenhua [2 ]
Qian, Xuhong [1 ,2 ]
Yang, Youjun [1 ,2 ]
机构
[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China
基金
中国国家自然科学基金;
关键词
Radicals; Fluorescent probe; Covalent assembly; Nitrogen dioxide; Fluorogenic; FLUORESCENT-PROBE; REACTIVE OXYGEN; NITRIC-OXIDE; LIVING CELLS; PEROXYNITRITE; GLUTATHIONE; DEFENSE; ACID; HG2+;
D O I
10.1016/j.cclet.2017.09.023
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Radical detection has attracted significant attention recently. Here we have developed a scaffold through covalent assembly principle (OR570), which could facile applications in detection of oxidative radicals. The primary advantage of the assembly type probe lies at the turn-on fluorescence signal from a zero background and hence high fluorescence turn-on ratio for sensitive detection of weak signal. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:2001 / 2004
页数:4
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