T-type Calcium Channels in Cancer

被引：49
|
作者：
Antal, Lauren [1 ]
Martin-Caraballo, Miguel [1 ]
机构：
[1] Univ Maryland Eastern Shore, Sch Pharm, Dept Pharmaceut Sci, Princess Anne, MD 21853 USA
来源：
CANCERS | 2019年 / 11卷 / 02期
关键词：
T-type Ca2+ channel; cancer; proliferation; neuroendocrine differentiation; CA2+ CHANNEL; PROSTATE-CANCER; BREAST-CANCER; NEUROENDOCRINE DIFFERENTIATION; CELL-PROLIFERATION; MEMBRANE EXPRESSION; OVARIAN-CANCER; SUBUNIT; INHIBITION; ALPHA(2)DELTA;
D O I：
10.3390/cancers11020134
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although voltage-activated Ca2+ channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+ channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca2+ channels may regulate a variety of Ca2+-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca2+ channels is of special interest as a target for therapeutic interventions.
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页数：18
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