The Julia-Colonna epoxidation:: Access to chiral, non-racemic epoxides

被引：17
|
作者：
Geller, T
Gerlach, A
Krüger, CM
Militzer, HC
机构：
[1] Bayer CropSci AG, Proc Res, D-40789 Monheim, Germany
[2] Bayer CropSci AG, Proc Res, D-65926 Frankfurt, Germany
[3] Wolff Cellulosics GmbH, D-29655 Walsrode, Germany
[4] Bayer HealthCare AG, Chem Dev, D-42096 Wuppertal, Germany
来源：
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2006年 / 251卷 / 1-2期
关键词：
epoxidation; asymmetric; polyanuno acid; peptide phase transfer catalysis;
D O I：
10.1016/j.molcata.2006.02.003
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The co-catalysis of the Julia-Colonna epoxidation with selected phase transfer catalysts results in a dramatic increase of reactivity and sometimes also in a higher enantiomeric excess of the product. The required amount of polyamino acid can be significantly reduced under the new conditions, such that large scale industrial application of the method is now feasible. Highly active catalyst can be prepared via a statistical polymerisation of leucine-N-carboxyanhydride at elevated temperature. (c) 2006 Elsevier B.V All rights reserved.
引用
收藏
页码：71 / 77
页数：7
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