Expanding biomarkers for PARP inhibitors

被引：2

作者：

Coussy, Florence ^{[1
,2
]}

Bidard, Francois-Clement ^{[1
,2
,3
,4
]}

机构：

[1] Inst Curie, Dept Med Oncol, Paris, France

[2] Inst Curie, Dept Med Oncol, St Cloud, France

[3] Univ Paris Saclay, UVSQ, St Cloud, France

[4] Inserm CIC BT 1428, Paris, France

来源：

NATURE CANCER | 2022年 / 3卷 / 10期

关键词：

METASTATIC BREAST-CANCER; OLAPARIB;

D O I：

10.1038/s43018-022-00440-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The efficacy of talazoparib and other PARP inhibitors has been primarily reported in germline BRCA mutation carriers. New results establish germline mutations in PALB2, but not in other homologous recombination (HR) genes, as targets for PARP inhibitors in breast cancer, whereas the added predictive value of HR signatures remains uncertain.

引用

页码：1141 / 1143

页数：3

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