Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative

被引：90

作者：

Kashtan, Clifford E. ^{[1
]}

Ding, Jie ^{[2
]}

Gregory, Martin ^{[3
]}

Gross, Oliver ^{[4
]}

Heidet, Laurence ^{[5
,6
]}

Knebelmann, Bertrand ^{[5
,6
]}

Rheault, Michelle ^{[1
]}

Licht, Christoph ^{[7
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Pediat, Div Pediat Nephrol, Minneapolis, MN 55455 USA

[2] Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China

[3] Univ Utah, Hlth Sci Ctr, Div Nephrol, Salt Lake City, UT USA

[4] Univ Med Goettingen, Dept Nephrol & Rheumatol, Gottingen, Germany

[5] Hop Necker Enfants Malad, Ctr Reference Malad Renales Hereditaires Enfant &, Paris, France

[6] Hop Necker Enfants Malad, Serv Nephrol Pediat, Paris, France

[7] Hosp Sick Children, Div Nephrol, Toronto, ON M5G 1X8, Canada

来源：

PEDIATRIC NEPHROLOGY | 2013年 / 28卷 / 01期

关键词：

Alport syndrome; Proteinuria; Angiotensin-converting enzyme inhibitor; Angiotensin receptor blocker; Aldosterone inhibitor; GENOTYPE-PHENOTYPE CORRELATIONS; DELAYS RENAL-FAILURE; PROLONGS SURVIVAL; NATURAL-HISTORY; BLOOD-PRESSURE; 195; FAMILIES; CHILDREN; INHIBITOR; FIBROSIS; EFFICACY;

D O I：

10.1007/s00467-012-2138-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin-angiotensin-aldosterone system.

引用

页码：5 / 11

页数：7

共 50 条

[1] Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative
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Martin Gregory
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Michelle Rheault
Christoph Licht
[J]. Pediatric Nephrology, 2013, 28 : 5 - 11
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